ArticleNutrition & metabolism2010
Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study.
Article in Nutrition & metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Association of Coffee and Tea Intake with Bone Mineral Density and Hip Fracture: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis.Public health nutrition · 2015Pooled it
- Review
- Caffeine consumption as a potential risk factor of osteoporosis development among night shift workers: epidemiological evidences and hypothesis.International journal of occupational medicine and environmental health · 2025Review
- Association between dietary intake, body measurements, and urinary bone resorption markers in young adults with osteopenia and osteoporosis: a cross-sectional study.Korean journal of community nutrition · 2023Article
- Coffee Brews: Are They a Source of Macroelements in Human Nutrition?Foods (Basel, Switzerland) · 2021Review
- Quantile-Specific Heritability may Account for Gene-Environment Interactions Involving Coffee Consumption.Behavior genetics · 2020Article
- Caffeine and Exercise: What Next?Sports medicine (Auckland, N.Z.) · 2019Review
- Does coffee drinking have beneficial effects on bone health of Taiwanese adults? A longitudinal study.BMC public health · 2018Article
- Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men.Journal of health, population, and nutrition · 2016Article
- The Association between Coffee Consumption and Bone Status in Young Adult Males according to Calcium Intake Level.Clinical nutrition research · 2016Article
- Associations between frequency of coffee consumption and osteoporosis in Chinese postmenopausal women.International journal of clinical and experimental medicine · 2015Article
- Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains.TheScientificWorldJournal · 2014Article
- Coffee consumption and bone mineral density in korean premenopausal women.Korean journal of family medicine · 2014Article
- Article
- Coffee consumption and risk of fractures: a meta-analysis.Archives of medical science : AMS · 2012Article
- The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine.Journal of the International Society of Sports Nutrition · 2012Article
- Lifestyle, dietary habits and consumption pattern of male university students according to the frequency of commercial beverage consumptions.Nutrition research and practice · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrinking coffee has been linked to reduced calcium conservation, but it is less clear whether it leads to sustained bone mineral loss and if individual predisposition for caffeine metabolism might be important in this context. Therefore, the relation between consumption of coffee and bone mineral density (BMD) at the proximal femur in men and women was studied, taking into account, for the first time, genotypes for cytochrome P450 1A2 (CYP1A2) associated with metabolism of caffeine.
methodsDietary intakes of 359 men and 358 women (aged 72 years), participants of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), were assessed by a 7-day food diary. Two years later, BMD for total proximal femur, femoral neck and trochanteric regions of the proximal femur were measured by Dual-energy X-ray absorptiometry (DXA). Genotypes of CYP1A2 were determined. Adjusted means of BMD for each category of coffee consumption were calculated.
resultsMen consuming 4 cups of coffee or more per day had 4% lower BMD at the proximal femur (p = 0.04) compared with low or non-consumers of coffee. This difference was not observed in women. In high consumers of coffee, those with rapid metabolism of caffeine (C/C genotype) had lower BMD at the femoral neck (p = 0.01) and at the trochanter (p = 0.03) than slow metabolizers (T/T and C/T genotypes). Calcium intake did not modify the relation between coffee and BMD.
conclusionHigh consumption of coffee seems to contribute to a reduction in BMD of the proximal femur in elderly men, but not in women. BMD was lower in high consumers of coffee with rapid metabolism of caffeine, suggesting that rapid metabolizers of caffeine may constitute a risk group for bone loss induced by coffee.
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Registered trials
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