ArticleRespiratory research2010
Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Correction to: Effects of liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation.Respiratory research · 2025Article
- Administration of GDF3 Into Septic Mice Improves SurvivalFrontiers in immunology · 2021Article
- Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-BioMed research international · 2017Article
- Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.The Journal of biological chemistry · 2016Article
- Age-dependent therapeutic effects of liver X receptor-α activation in murine polymicrobial sepsis.Innate immunity · 2015Article
- Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury.Circulation. Heart failure · 2014Article
- A liver-X-receptor ligand, T0901317, attenuates IgE production and airway remodeling in chronic asthma model of mice.PloS one · 2014Article
- Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice.Mediators of inflammation · 2014Article
- Emerging roles for cholesterol and lipoproteins in lung disease.Pulmonary pharmacology & therapeutics · 2013Article
- Anti-inflammatory effects of adrenomedullin on acute lung injury induced by Carrageenan in mice.Mediators of inflammation · 2012Article
- Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.Shock (Augusta, Ga.) · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver x receptor alpha (LXRalpha) and beta (LXRbeta) are members of the nuclear receptor super family of ligand-activated transcription factors, a super family which includes the perhaps better known glucocorticoid receptor, estrogen receptor, thyroid receptor, and peroxisome proliferator-activated receptors. There is limited evidence that LXL activation may reduces acute lung inflammation. The aim of this study was to investigate the effects of T0901317, a potent LXR receptor ligand, in a mouse model of carrageenan-induced pleurisy.
methodsInjection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), tumor necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta). Furthermore, carrageenan induced the expression of iNOS, nitrotyrosine and PARP, as well as induced apoptosis (TUNEL staining and Bax and Bcl-2 expression) in the lung tissues.
resultsAdministration of T0901317, 30 min after the challenge with carrageenan, caused a significant reduction in a dose dependent manner of all the parameters of inflammation measured.
conclusionsThus, based on these findings we propose that LXR ligand such as T0901317, may be useful in the treatment of various inflammatory diseases.
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