ArticleBMC cancer2010
Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Human papillomavirus infection by anatomical site among Greek men and women: a systematic review.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2016Pooled it
- Neutrophil/lymphocyte ratio predicts lymph node metastasis in patients with gastric cancer.American journal of translational research · 2023Article
- Comparison of the performance of HPV DNA chip test and HPV PCR test in cervical cancer screening in rural China.Frontiers in microbiology · 2022Article
- Comparison between self sampling and provider collected samples for Human Papillomavirus (HPV) Deoxyribonucleic acid (DNA) testing in a Nigerian facility.The Pan African medical journal · 2018Article
- Comparison of DNA testing strategies in monitoring human papillomavirus infection prevalence through simulation.BMC infectious diseases · 2016Article
- Diagnostic algorithm to reflect regressive changes of human papilloma virus in tissue biopsies.Yonsei medical journal · 2014Article
- The cytology and DNA detection by the PapilloCheck(®) test in the diagnosis of human papillomavirus infection.European journal of microbiology & immunology · 2013Article
- Human papillomavirus (HPV) detection using in situ hybridization in histologic samples: correlations with cytologic changes and polymerase chain reaction HPV detection.American journal of clinical pathology · 2011Article
- Ancillary studies in determining human papillomavirus status of squamous cell carcinoma of the oropharynx: a review.Pathology research international · 2011Article
- Performance evaluation of manual and automated (MagNA pure) nucleic acid isolation in HPV detection and genotyping using Roche Linear Array HPV Test.Infectious diseases in obstetrics and gynecology · 2011Article
- Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence.Infectious diseases in obstetrics and gynecology · 2011Article
- Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma.Virology journal · 2010Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated two molecular methods of HPV detection and their correlation with cytological and histological diagnosis in a large sample of Greek women.
methodsAll women with liquid-based cytology performed at a University Hospital between 2000 and 2003 were included. The Hybrid Capture 2 (HC2) kit and in house Polymerase Chain Reaction (PCR) were used for HPV DNA detection. Cervical biopsy was performed for women with ASCUS+ cytology, HPV detection, or abnormal colposcopy. Positive (PLR) and negative (NLR) likelihood ratios were calculated for cytology and HPV molecular testing for the prediction of CIN2 and greater histology.
resultsOf the 1270 women evaluated 241 (18.5%) had abnormal cytology. Cytology diagnosed high-grade squamous intraepithelial lesion (HSIL) or invasive carcinoma in 21(1.7%) cases whereas 26 (2%) women had CIN2+ or greater histology. PCR detected HPV in 397/1270 (31.3%) and HC2 in 260/1270 (20.4%) samples. Both molecular tests exhibited high reproducibility (Cohen's kappa value 0.691, 95% CI: 0.664 - 0.718). Positive likelihood ratios (PLR) of 9.4, 3.8 and 3.4 and negative likelihood ratios of 0.13, 0.21, and 0 were noted for >or= LSIL, any positive HC2 or any positive PCR-HPV testing, for predicting CIN2+ histology, respectively. All CIN 3+ lesions harbored high risk oncogenic HPV type infections.
conclusionsHPV infection was found in a large proportion of this population and was associated with CIN 2/3 lesions and infiltrating carcinomas. Thin prep testing and HPV detection by HC2 or PCR performed very well with regards to identifying high grade lesions in an environment with experienced examiners.
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