Trial reportSleep2010
Age-related reduction in daytime sleep propensity and nocturnal slow wave sleep.
Trial report in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 3 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- Pooled it
- The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research.Sleep medicine reviews · 2020Pooled it
- The association between slow wave activity and memory improvement following cognitive-behavioral therapy for insomnia in older adults: A secondary analysis of a randomized clinical trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Trial
- Loneliness and social isolation is associated with sleep problems among older community dwelling women and men with complex needs.Scientific reports · 2021Trial
- Memory improvement via slow-oscillatory stimulation during sleep in older adults.Neurobiology of aging · 2015Trial
- Cognitive workload and sleep restriction interact to influence sleep homeostatic responses.Sleep · 2014Trial
- Impact of acetazolamide and CPAP on cortical activity in obstructive sleep apnea patients.PloS one · 2014Trial
- EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2011Trial
- Differences in insomnia-related factors between working-age and older adults: A comparison of nocturnal and daytime symptoms.Sleep medicine: X · 2026Article
- Italian Quebec Sleep Questionnaire for assessing quality of life in obstructive sleep apnoea.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Article
- How Well Do Young Male Semi-Professional Soccer Players Sleep During an Afternoon Nap?Clocks & sleep · 2026Article
- Human data at odds and in confirmation of the two-process model of sleep regulation-a perspective.Npj biological timing and sleep · 2026Review
- Sleep duration and depressive symptoms among older Chinese adults: a serial mediation model of self-rated health and frailty.BMC geriatrics · 2026Article
- Albumin/creatinine ratio thresholds associated with poor sleep quality in elderly obese non-diabetic individuals: a cross-sectional study.BMC nephrology · 2026Article
- Sleep stage-specific effects of 0.75 Hz phase-synchronized rTMS and tACS on delta frequency activity during sleep.Scientific reports · 2026Article
- A data-driven measure of REM sleep propensity for human and rodent sleep.Frontiers in neuroscience · 2026Article
- Sleep and Aging. A Polysomnographic Follow-Up Study, Some 40 Years Later.Journal of sleep research · 2025Article
- Deep sleep homeostatic response to naturalistic sleep loss.PLOS digital health · 2025Article
- Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether age-related and experimental reductions in SWS and sleep continuity are associated with increased daytime sleep propensity.
methodsAssessment of daytime sleep propensity under baseline conditions and following experimental disruption of SWS. Healthy young (20-30 y, n = 44), middle-aged (40-55 y, n = 35) and older (66-83 y, n = 31) men and women, completed a 2-way parallel group study. After an 8-h baseline sleep episode, subjects were randomized to 2 nights with selective SWS disruption by acoustic stimuli, or without disruption, followed by 1 recovery night. Objective and subjective sleep propensity were assessed using the Multiple Sleep Latency Test (MSLT) and the Karolinska Sleepiness Scale (KSS).
findingsDuring baseline sleep, SWS decreased (P < 0.001) and the number of awakenings increased (P < 0.001) across the 3 age groups. During the baseline day, MSLT values increased across the three age groups (P < 0.0001) with mean values of 8.7 min (SD: 4.5), 11.7 (5.1) and 14.2 (4.1) in the young, middle-aged, and older adults, respectively. KSS values were 3.7 (1.0), 3.2 (0.9), and 3.4 (0.6) (age-group: P = 0.031). Two nights of SWS disruption led to a reduction in MSLT and increase in KSS in all 3 age groups (SWS disruption vs. control: P < 0.05 in all cases).
conclusionsHealthy aging is associated with a reduction in daytime sleep propensity, sleep continuity, and SWS. In contrast, experimental disruption of SWS leads to an increase in daytime sleep propensity. The age-related decline in SWS and reduction in daytime sleep propensity may reflect a lessening in homeostatic sleep requirement. Healthy older adults without sleep disorders can expect to be less sleepy during the daytime than young adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.