ArticleSynapse (New York, N.Y.)2010
Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice.
Article in Synapse (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors.Frontiers in psychiatry · 2019Article
- Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice.Frontiers in molecular neuroscience · 2018Article
- Article
- To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.Frontiers in integrative neuroscience · 2018Article
- The dopamine motive system: implications for drug and food addiction.Nature reviews. Neuroscience · 2017Review
- EFFECTS OF METHAMPHETAMINE ON LOCOMOTOR ACTIVITY AND THALAMIC GENE EXPRESSION IN LEPTIN-DEFICIENT OBESE MICE.Translational brain rhythmicity · 2017Article
- Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward.Translational psychiatry · 2016Article
- Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation.Biological psychiatry · 2016Article
- Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.Oncotarget · 2016Article
- High on food: the interaction between the neural circuits for feeding and for reward.Frontiers in biology · 2015Article
- Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: implications of food intake.Molecular medicine reports · 2014Article
- Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system.Frontiers in psychology · 2014Review
- Circannual changes in stress and feeding hormones and their effect on food-seeking behaviors.Frontiers in neuroscience · 2013Article
- Social stress interacts with diet history to promote emotional feeding in females.Psychoneuroendocrinology · 2012Article
- Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement.Molecular psychiatry · 2012Article
- Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism.Molecular metabolism · 2012Article
- Metabolic and hedonic drives in the neural control of appetite: who is the boss?Current opinion in neurobiology · 2011Review
- Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R-binding differences contribute to the phenotypic behaviors of leptin-deficient ob/ob mice, and whether D2R binding is altered in response to peripheral leptin treatment in these mice. Leptin decreased body weight, food intake, and plasma insulin concentration in ob/ob mice but not in wild-type mice. Basal striatal D2R binding (measured with autoradiography [(3)H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. Our findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.