ArticleJournal of neuro-oncology2010
Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Expression and Prognostic Significance of p53 in Glioma Patients: A Meta-analysis.Neurochemical research · 2016Pooled it
- Searching for a cut-off point for p53 immunohistochemistry as evidence of TP53 mutations.Free neuropathology · 2024Article
- Article
- Molecular landscape of pediatric type IDH wildtype, H3 wildtype hemispheric glioblastomas.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- Rare case of renal Ewing sarcoma presenting as ectopic Cushing syndrome in a 12-year-old girl.BMJ case reports · 2022Article
- Multicentric glioblastoma in a 4-year-old female patient: A case report.Molecular and clinical oncology · 2021Article
- Main genetic differences in high-grade gliomas may present different MR imaging and MR spectroscopy correlates.European radiology · 2021Article
- Recent Trends of microRNA Significance in Pediatric Population Glioblastoma and Current Knowledge of Micro RNA Function in Glioblastoma Multiforme.International journal of molecular sciences · 2020Review
- Epigenetic Reprogramming for TargetingCancers · 2019Review
- National cancer database analysis of outcomes in pediatric glioblastoma.Cancer medicine · 2018Article
- Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival.Chinese journal of cancer · 2016Article
- Clinical outcome and molecular characterization of pediatric glioblastoma treated with postoperative radiotherapy with concurrent and adjuvant temozolomide: a single institutional study of 66 children.Neuro-oncology practice · 2016Article
- Prognostic Value of Metabolic Tumor Volume on (11)C-Methionine PET in Predicting Progression-Free Survival in High-Grade Glioma.Nuclear medicine and molecular imaging · 2015Article
- Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity.Brain pathology (Zurich, Switzerland) · 2015Article
- IDH1 Mutation in Gliomas in Mosul City - Iraq.Open access Macedonian journal of medical sciences · 2015Article
- Isocitrate dehydrogenase 1 mutations (IDH1) and p16/CDKN2A copy number change in conventional chondrosarcomas.Virchows Archiv : an international journal of pathology · 2015Article
- Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment.BioMed research international · 2015Review
- Article
- The genetic signatures of pediatric high-grade glioma: no longer a one-act play.Seminars in radiation oncology · 2014Review
- Unveiling YKL-40, from Serum Marker to Target Therapy in Glioblastoma.Frontiers in oncology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate, in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma WHO grade III and 22 glioblastoma WHO grade IV), the prognostic value of histological grading and expression of p53 and YKL-40. Moreover, mutational screening for TP53 and IDH1 was performed in 27 of 43 cases. The prognostic stratification for histological grading showed no difference in overall (OS) and progression-free survival (PFS) between glioblastomas and anaplastic astrocytomas. Overexpression of YKL40 was detected in 25 of 43 (58%) cases, but YKL-40 expression was not prognostic in terms of OS and PFS. p53 protein expression was observed in 13 of 43 (31%) cases but was not prognostic. TP53 mutations were detected in five of 27 (18%) cases (four glioblastomas and one anaplastic astrocytoma). Patients with TP53 mutation had a shorter median OS (9 months) and PFS (8 months) than those without mutations (OS, 17 months; PFS, 16 months), although this trend did not reach statistical significance (p = 0.07). IDH1 mutations were not detected in any of the cases analyzed. Our results suggest that in pediatric high-grade gliomas: (i) histological grading does not have strong prognostic significance, (ii) YKL-40 overexpression is less frequent than adult high-grade gliomas and does not correlate with a more aggressive behavior, (iii) TP53 mutations but not p53 expression may correlate with a more aggressive behavior, and (iv) IDH1 mutations are absent. These observations support the concept that, despite identical histological features, the biology of high-grade gliomas in children differs from that in adults, and therefore different prognostic factors are needed.
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