ArticleJournal of cancer research and clinical oncology2010
Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes.
Article in Journal of cancer research and clinical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Association Between Free Triiodothyronine and Carcinoembryonic Antigen Levels in Type 2 Diabetes Mellitus Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Clinical significance of tumor markers in patients with type 2 diabetes: a retrospective observational study.Diabetology international · 2023Article
- Diabetes and pancreatic cancer: Exploring the two-way traffic.World journal of gastroenterology · 2021Review
- Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer.Oncology letters · 2020Article
- Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.Oncotarget · 2018Article
- Review
- HbA1c is Positively Associated with Serum Carcinoembryonic Antigen (CEA) in Patients with Diabetes: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2018Article
- Association between serum carcinoembryonic antigen level and oxidative stress parameters among diabetic females.International journal of clinical and experimental medicine · 2015Article
- Pancreatic cancer presenting as new-onset diabetes.Case reports in oncology · 2014Article
- Relationship between Serum Level of Lymphatic Vessel Endothelial Hyaluronan Receptor-1 and Prognosis in Patients with Lung Cancer.Journal of Cancer · 2014Article
- The bidirectional interation between pancreatic cancer and diabetes.World journal of surgical oncology · 2012Review
- Reversible high blood CEA and CA19-9 concentrations in a diabetic patient.The Libyan journal of medicine · 2012Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between diabetes and pancreatic cancer has been established by more than several decades of research. However, serum levels of CEA and CA 19-9 in diabetic pancreatic cancer has not been shown.
methodsPreoperative serum levels of CEA and CA 19-9 and clinicopathological characteristics were retrospectively analyzed in 79 with or 229 without diabetes in pancreatic ductal adenocarcinoma (PDA) patients.
resultsOf the 308 PDA patients enrolled, 79 (25.6%) patients had diabetes. The percentage of new-onset diabetes (i.e. <24 months in duration) was 57% (45/79) in PDA patients coupled with diabetes. Among diabetic PDA patients, mean total bilirubin and fasting blood glucose significantly increased in comparison with control groups (8.54 ± 14.88 vs. 4.16 ± 6.12; 170.22 ± 106.96 vs. 95.84 ± 15.76; P < 0.05). No significant differences were observed in mean levels of serum CA 19-9 and CEA levels between two groups. However, when the value of CEA and CA 19-9 was analyzed as a dichotomous variable, elevated CEA (≥5 ng/ml) and CA 19-9 (≥500 U/ml) levels were strongly correlated with the presence of diabetes in PDA patients.
conclusionElevated CEA (≥5 ng/ml) and CA19-9 (≥500 U/ml) levels have an association with diabetic pancreatic cancer. New-onset diabetes combined with higher CA 19-9 and/or CEA might be regarded as a useful tool to screen early pancreatic cancer.
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