ReviewJournal of molecular medicine (Berlin, Germany)2010
Insights into lysosomal cobalamin trafficking: lessons learned from cblF disease.
Review in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Animal models of methylmalonic acidemia: insights and challenges.Orphanet journal of rare diseases · 2025Review
- Microscopic, stereological, and biochemical investigation of the effects of vitamin B12 on vascular changes in an experimental subarachnoid hemorrhage model in rats.Neurosurgical review · 2025Article
- CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.Biomolecules · 2024Article
- Vitamin BMolecules (Basel, Switzerland) · 2022Review
- Review
- Assessment of cellular cobalamin metabolism in Gaucher disease.BMC medical genetics · 2020Article
- Review
- Lmbrd1 expression is essential for the initiation of gastrulation.Journal of cellular and molecular medicine · 2016Article
- Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.Scientific reports · 2016Article
- Propofol administration in patients with methylmalonic acidemia and intracellular cobalamin metabolism disorders: a review of theoretical concerns and clinical experiences in 28 patients.Journal of inherited metabolic disease · 2015Review
- Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency.Molecular nutrition & food research · 2015Review
- Article
- Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition.Bioscience reports · 2014Article
- Evidence of an evolutionarily conserved LMBR1 domain-containing protein that associates with endocytic cups and plays a role in cell migration in dictyostelium discoideum.Eukaryotic cell · 2012Article
- Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking?Cellular and molecular life sciences : CMLS · 2011Review
- Dissecting the role of vitamin BDifferentiation; research in biological diversityReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin B(12) (cobalamin) is essential in animals and humans for metabolism of methylmalonic acid, for the remethylation of homocysteine to methionine and, consequently, for all S-adenosylmethionine-dependent methylation reactions, including DNA synthesis. In man, cobalamin deficiency leads to anemia and neurologic and cognitive impairment. In the cblF inborn error of vitamin B(12) metabolism, free vitamin accumulates in lysosomes and cannot be converted to cofactors for mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase. Recent work has shown that this defect is caused by mutations in the lysosomal membrane protein LMBD1, which shows significant homology to lipocalin membrane receptors, thereby indicating that LMBD1 is a lysosomal membrane exporter for cobalamin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.