ArticlePloS one2010
Intra-cluster percolation of calcium signals.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Modeling traveling calcium waves in cellular structures.Journal of computational neuroscience · 2025Article
- Biological physics to uncover cell signaling.Biophysical reviews · 2025Review
- Modeling somatic computation with non-neural bioelectric networks.Scientific reports · 2019Article
- Changes in CaFrontiers in physiology · 2019Article
- Article
- Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.European journal of pharmacology · 2014Review
- Basis for a neuronal version of Grover's quantum algorithm.Frontiers in molecular neuroscience · 2014Article
- Article
- Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs.Biophysical journal · 2013Article
- Towards the Physics of Calcium Signalling in Plants.Plants (Basel, Switzerland) · 2013Review
- Multi-scale data-driven modeling and observation of calcium puffs.Cell calcium · 2012Article
- Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.Frontiers in physiology · 2012Article
- Inositol (1,4,5)-trisphosphate receptor microarchitecture shapes Ca2+ puff kinetics.Biophysical journal · 2011Article
- Mean field strategies induce unrealistic non-linearities in calcium puffs.Frontiers in physiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's areusually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme case sis similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+-mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior.
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