ArticlePloS one2010
Skeletal muscle phenotypically converts and selectively inhibits metastatic cells in mice.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- TRF2 couples muscle stem cell identity to regenerative repair.Science advances · 2026Article
- Prognostic Value of Psoas Major Muscle Volume in Assessing Sarcopenia in Elderly Patients With Rectal Cancer.Annals of gastroenterological surgery · 2026Article
- DUSP29 does not regulate melanoma-myoblast interactions in a skeletal muscle co-culture model.Scientific reports · 2026Article
- Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell's anti-proliferative effect on cancer cells.Oncogenesis · 2026Article
- Article
- Striated muscle: an inadequate soil for cancers.Cancer metastasis reviews · 2024Review
- How much do we know about the metastatic process?Clinical & experimental metastasis · 2024Review
- Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells.Nature cell biology · 2022Article
- Article
- Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy.Cell reports · 2019Article
- Physical Activity Counteracts Tumor Cell Growth in Colon Carcinoma C26-Injected Muscles: An Interim Report.European journal of translational myology · 2016Article
- Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Melanoma metastasis: new concepts and evolving paradigms.Oncogene · 2014Review
- Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle.American journal of physiology. Cell physiology · 2013Article
- Role of pericytes in skeletal muscle regeneration and fat accumulation.Stem cells and development · 2013Article
- 'Hearts and bones': the ups and downs of 'plasticity' in stem cell biology.EMBO molecular medicine · 2012Review
- MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.Nature · 2012Article
- Decoding melanoma metastasis.Cancers · 2010Article
- The road less travelled: Skeletal muscle invasion in oral squamous cell carcinoma.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Skeletal muscle is rarely a site of malignant metastasis; the molecular and cellular basis for this rarity is not understood. We report that myogenic cells exert pronounced effects upon co-culture with metastatic melanoma (B16-F10) or carcinoma (LLC1) cells including conversion to the myogenic lineage in vitro and in vivo, as well as inhibition of melanin production in melanoma cells coupled with cytotoxic and cytostatic effects. No effect is seen with non-tumorigenic cells. Tumor suppression assays reveal that the muscle-mediated tumor suppressor effects do not generate resistant clones but function through the down-regulation of the transcription factor MiTF, a master regulator of melanocyte development and a melanoma oncogene. Our findings point to skeletal muscle as a source of therapeutic agents in the treatment of metastatic cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.