ArticlePLoS genetics2010
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 23 of them syntheses that pooled it.
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Who cites it
190 citing papers in PubMed, 23 syntheses or guidelines pooled it, 348 citations in OpenAlex.
- Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing.Journal of biomedical science · 2025Pooled it
- Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.Nature genetics · 2022Pooled it
- A pathway analysis of genome-wide association study highlights novel type 2 diabetes risk pathways.Scientific reports · 2017Pooled it
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- Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?Diabetologia · 2014Pooled it
- Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.PLoS genetics · 2014Pooled it
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.Nature genetics · 2014Pooled it
- Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes.PloS one · 2014Pooled it
- Pooled it
- Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.Diabetologia · 2013Pooled it
- Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes.Molecular biology reports · 2013Pooled it
- Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.Diabetes · 2013Pooled it
- Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.Diabetes · 2013Pooled it
- Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.PloS one · 2013Pooled it
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.Nature genetics · 2012Pooled it
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.American journal of human genetics · 2012Pooled it
- The association between KCNQ1 gene polymorphism and type 2 diabetes risk: a meta-analysis.PloS one · 2012Pooled it
- Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.Nature genetics · 2011Pooled it
130 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese population. A two-stage genome-wide association (GWA) study was conducted, in which 995 patients and 894 controls were genotyped using the Illumina HumanHap550-Duo BeadChip for the first genome scan stage. This was further replicated in 1,803 patients and 1,473 controls in stage 2. We found two loci not previously associated with diabetes susceptibility in and around the genes protein tyrosine phosphatase receptor type D (PTPRD) (P = 8.54x10(-10); odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.36-1.82), and serine racemase (SRR) (P = 3.06x10(-9); OR = 1.28; 95% CI = 1.18-1.39). We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65x10(-10); OR = 1.29, 95% CI = 1.19-1.40). By identifying two novel genetic susceptibility loci in a Han Chinese population and confirming the involvement of KCNQ1, which was previously reported to be associated with T2D in Japanese and European descent populations, our results may lead to a better understanding of differences in the molecular pathogenesis of T2D among various populations.
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