ArticlePLoS genetics2010
Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators.Biomolecules · 2023Review
- Inactive Proteasomes Routed to Autophagic Turnover Are Confined within the Soluble Fraction of the Cell.Biomolecules · 2022Article
- Review
- Histones on fire: the effect of Dun1 and Mrc1 on origin firing and replication of hyper-acetylated genomes.Current genetics · 2021Review
- Mutant thermal proteome profiling for characterization of missense protein variants and their associated phenotypes within the proteome.The Journal of biological chemistry · 2020Article
- Precise Replacement ofG3 (Bethesda, Md.) · 2020Article
- Genomic analyses reveal distinct genetic architectures and selective pressures in buffaloes.GigaScience · 2020Article
- EssentialProceedings of the National Academy of Sciences of the United States of America · 2019Article
- One rogue agent suffices for genomic chaos.Nature · 2019Article
- Taxonomically Restricted Genes with Essential Functions Frequently Play Roles in Chromosome Segregation inG3 (Bethesda, Md.) · 2017Article
- Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome.Science (New York, N.Y.) · 2017Article
- Article
- Genetic instability in budding and fission yeast-sources and mechanisms.FEMS microbiology reviews · 2015Review
- An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.G3 (Bethesda, Md.) · 2015Article
- The protein quality control machinery regulates its misassembled proteasome subunits.PLoS genetics · 2015Article
- Replisome function during replicative stress is modulated by histone h3 lysine 56 acetylation through Ctf4.Genetics · 2015Article
- Deubiquitinases and the new therapeutic opportunities offered to cancer.Endocrine-related cancer · 2015Review
- Review
- Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.Nucleic acids research · 2013Article
- Formation and dissociation of proteasome storage granules are regulated by cytosolic pH.The Journal of cell biology · 2013Article
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7 authors.
Funding
Abstract
To expand the known spectrum of genes that maintain genome stability, we screened a recently released collection of temperature sensitive (Ts) yeast mutants for a chromosome instability (CIN) phenotype. Proteasome subunit genes represented a major functional group, and subsequent analysis demonstrated an evolutionarily conserved role in CIN. Analysis of individual proteasome core and lid subunit mutations showed that the CIN phenotype at semi-permissive temperature is associated with failure of subunit localization to the nucleus. The resultant proteasome dysfunction affects chromosome stability by impairing the kinetics of double strand break (DSB) repair. We show that the DNA repair protein Mms22 is required for DSB repair, and recruited to chromatin in a ubiquitin-dependent manner as a result of DNA damage. Moreover, subsequent proteasome-mediated degradation of Mms22 is necessary and sufficient for cell cycle progression through the G(2)/M arrest induced by DNA damage. Our results demonstrate for the first time that a double strand break repair protein is a proteasome target, and thus link nuclear proteasomal activity and DSB repair.
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