ArticleOptics express2010
Diffusive and directional intracellular dynamics measured by field-based dynamic light scattering.
Article in Optics express, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review of dynamic optical coherence tomography for intracellular motility: signals, metrics, and their applications [Invited].Biomedical optics express · 2025Review
- Dynamic light scattering microscopy sensing mitochondria dynamics for label-free detection of triple-negative breast cancer enhanced by deep learning.Biomedical optics express · 2023Article
- Intracellular optical doppler phenotypes of chemosensitivity in human epithelial ovarian cancer.Scientific reports · 2020Article
- Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue.Journal of biomedical optics · 2020Article
- Cell viscoelasticity is linked to fluctuations in cell biomass distributions.Scientific reports · 2020Article
- Forward multiple scattering dominates speckle decorrelation in whole-blood flowmetry using optical coherence tomography.Biomedical optics express · 2020Article
- Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography.Investigative ophthalmology & visual science · 2019Article
- Biodynamic digital holography of chemoresistance in a pre-clinical trial of canine B-cell lymphoma.Biomedical optics express · 2018Article
- Article
- Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation.Biomedical optics express · 2013Article
- Application of optical imaging and spectroscopy to radiation biology.Radiation research · 2012Review
- Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex.Optics express · 2011Article
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Authors and funding
5 authors.
Funding
Abstract
Quantitative measurement of diffusive and directional processes of intracellular structures is not only critical in understanding cell mechanics and functions, but also has many applications, such as investigation of cellular responses to therapeutic agents. We introduce a label-free optical technique that allows non-perturbative characterization of localized intracellular dynamics. The method combines a field-based dynamic light scattering analysis with a confocal interferometric microscope to provide a statistical measure of the diffusive and directional motion of scattering structures inside a microscopic probe volume. To demonstrate the potential of this technique, we examined the localized intracellular dynamics in human epithelial ovarian cancer cells. We observed the distinctive temporal regimes of intracellular dynamics, which transitions from random to directional processes on a timescale of ~0.01 sec. In addition, we observed disrupted directional processes on the timescale of 1 approximately 5 sec by the application of a microtubule polymerization inhibitor, Colchicine, and ATP depletion.
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Registered trials
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