ArticleNucleic acids research1991
Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 96 citations in OpenAlex.
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- Diversity in sequence-dependent control of GRO chemokine mRNA half-life.Journal of leukocyte biology · 2013Article
- Post-transcriptional regulatory networks in immunity.Immunological reviews · 2013Review
- Cell type- and stimulus-specific mechanisms for post-transcriptional control of neutrophil chemokine gene expression.Journal of leukocyte biology · 2012Review
- Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC.International journal of colorectal disease · 2010Article
- Post-transcriptional regulons coordinate the initiation and resolution of inflammation.Nature reviews. Immunology · 2010Review
- Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Differential induction of immunoregulatory circuits of phagocytic cells by Gal/Gal NAc lectin from pathogenic and nonpathogenic Entamoeba.Journal of clinical immunology · 2008Article
- Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1.The Journal of biological chemistry · 2008Article
- The effect of infliximab on chemokines in patients with rheumatoid arthritis.Clinical rheumatology · 2007Article
- Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.Journal of clinical immunology · 2004Article
- Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.Molecular and cellular biology · 2003Article
- Balance of pro- and anti-inflammatory cytokines correlates with outcome of acute experimental Pseudomonas aeruginosa keratitis.Infection and immunity · 2002Article
- Importance of post-transcriptional regulation of chemokine genes by oxidative stress.The Biochemical journal · 2001Article
- Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression.Infection and immunity · 2001Article
- The 3'-untranslated region of human interleukin-8 mRNA suppresses IL-8 gene expression.Immunology · 2001Article
- Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients.Molecular and cellular biochemistry · 2001Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the cytokine gene gro, also known as melanoma growth stimulatory activity, is induced by inflammatory stimuli, including IL-1. To determine whether gro expression is regulated at a post-transcriptional level, the effect of IL-1 on gro mRNA stability was examined. Treatment of fibroblasts with IL-1 beta caused a dose-dependent induction of gro mRNA. When IL-1 was withdrawn, gro mRNA decayed rapidly with a half life of 1 hour. This decay occurred whether or not actinomycin D was added to block new transcription. In contrast, when IL-1 was present in the medium, the level of gro mRNA was stable over 8 hours following addition of actinomycin D. In addition, the stability of a related mRNA, IL-8, was found to be regulated by IL-1. To examine whether Northern results reflected expression of gro alpha, or of the closely related genes, gro beta and gro gamma, RNA samples were analyzed by PCR. All three genes were found to be induced by IL-1 and all mRNAs were stabilized in the presence of IL-1. Northern analysis revealed a minor species of gro mRNA which lacked poly(A). The pattern of expression of this RNA suggested that it was a decay intermediate of one or more of the gro mRNAs. The findings indicate that mRNA stabilization is an important component of IL-1 induced gene expression.
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