ArticleNucleic acids research1991
Transcript levels of the Saccharomyces cerevisiae DNA repair gene RAD18 increase in UV irradiated cells and during meiosis but not during the mitotic cell cycle.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins.The EMBO journal · 2024Article
- Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.Annual review of biophysics · 2015Review
- Meiotic functions of RAD18.Journal of cell science · 2011Article
- The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway.Nucleic acids research · 2001Article
- The 26S proteasome negatively regulates the level of overall genomic nucleotide excision repair.Nucleic acids research · 2000Article
- Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe.Molecular and cellular biology · 2000Article
- Regulation of the ribonucleotide reductase small subunit gene by DNA-damaging agents in Dictyostelium discoideum.Nucleic acids research · 1999Article
- Article
- The fission yeast UVDR DNA repair pathway is inducible.Nucleic acids research · 1997Article
- Regulation of SNM1, an inducible Saccharomyces cerevisiae gene required for repair of DNA cross-links.Molecular & general genetics : MGG · 1996Article
- Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage.Nucleic acids research · 1995Article
- Regulation of the Saccharomyces cerevisiae Srs2 helicase during the mitotic cell cycle, meiosis and after irradiation.Molecular & general genetics : MGG · 1995Article
- Regulation of the Saccharomyces cerevisiae DNA repair gene RAD16.Nucleic acids research · 1995Article
- Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae.Molecular and cellular biology · 1993Article
- SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.Molecular and cellular biology · 1993Article
- The REV3 gene of Saccharomyces cerevisiae is transcriptionally regulated more like a repair gene than one encoding a DNA polymerase.Molecular & general genetics : MGG · 1992Article
- Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51.Molecular and cellular biology · 1992Article
- Effects of bleomycin on growth kinetics and survival of Saccharomyces cerevisiae: a model of repair pathways.Journal of bacteriology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have examined the transcript levels of the Saccharomyces cerevisiae DNA repair gene RAD18 in UV irradiated cells, in the mitotic cell cycle, and during meiosis. Levels of RAD18 mRNA increased upon UV irradiation, but remained constant during the mitotic cell cycle. During meiosis, RAD18 mRNA levels rose about 4 fold at a stage coincident with the period when high levels of genetic recombination occur. RAD18 resembles the other DNA repair genes, RAD2, RAD6, RAD7, RAD23, and RAD54, all of which also exhibit increased transcription in response to DNA damage and during meiosis. Comparisons of sequences in 5' flanking regions of RAD genes suggest that different upstream sequences are involved in regulating the expression of DNA repair genes belonging to different epistasis groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.