ArticleApplied and environmental microbiology2010
Role of GlnR in acid-mediated repression of genes encoding proteins involved in glutamine and glutamate metabolism in Streptococcus mutans.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 36 citations in OpenAlex.
- Computational and preliminary screening of anti-caries active compounds of Caesalpinia sappan.Scientific reports · 2026Article
- GlnR positively affects the acid resistance ofFrontiers in microbiology · 2025Article
- ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication.PLoS pathogens · 2022Article
- Diaryl Urea Derivative Molecule Inhibits CariogenicFrontiers in cellular and infection microbiology · 2022Article
- Nicotinamide could reduce growth and cariogenic virulence ofJournal of oral microbiology · 2022Article
- Increased Oxidative Stress Tolerance of a Spontaneously OccurringJournal of bacteriology · 2021Article
- Identification and functional analysis of glutamine transporter inJournal of oral microbiology · 2020Article
- GlnR Negatively Regulates Glutamate-Dependent Acid Resistance in Lactobacillus brevis.Applied and environmental microbiology · 2020Article
- Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans.mSphere · 2020Article
- Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of aJournal of bacteriology · 2018Article
- Acid-adaptive mechanisms of Streptococcus mutans-the more we know, the more we don't.Molecular oral microbiology · 2017Review
- Modification of theMicrobial genomics · 2017Article
- [Development of transcriptional regulators of Streptococcus mutans in cariogenic virulence].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Review
- The GlnR Regulon in Streptococcus mutans Is Differentially Regulated by GlnR and PmrA.PloS one · 2016Article
- Article
- Catabolite control protein A is an important regulator of metabolism inBiomedical reports · 2014Article
- Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.BMC genomics · 2014Article
- Growth phase and pH influence peptide signaling for competence development in Streptococcus mutans.Journal of bacteriology · 2014Article
- Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans.Journal of oral microbiology · 2014Review
- Identification and functional analysis of an ammonium transporter in Streptococcus mutans.PloS one · 2014Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acid tolerance response (ATR) is one of the major virulence traits of Streptococcus mutans. In this study, the role of GlnR in acid-mediated gene repression that affects the adaptive ATR in S. mutans was investigated. Using a whole-genome microarray and in silico analyses, we demonstrated that GlnR and the GlnR box (ATGTNAN(7)TNACAT) were involved in the transcriptional repression of clusters of genes encoding proteins involved in glutamine and glutamate metabolism under acidic challenge. Reverse transcription-PCR (RT-PCR) analysis revealed that the coordinated regulation of the GlnR regulon occurred 5 min after acid treatment and that prolonged acid exposure (30 min) resulted in further reduction in expression. A lower level but consistent reduction in response to acidic pH was also observed in chemostat-grown cells, confirming the negative regulation of GlnR. The repression by GlnR through the GlnR box in response to acidic pH was further confirmed in the citBZC operon, containing genes encoding the first three enzymes in the glutamine/glutamate biosynthesis pathway. The survival rate of the GlnR-deficient mutant at pH 2.8 was more than 10-fold lower than that in the wild-type strain 45 min after acid treatment, suggesting that the GlnR regulon participates in S. mutans ATR. It is hypothesized that downregulation of the synthesis of the amino acid precursors in response to acid challenge would promote citrate metabolism to pyruvate, with the consumption of H(+) and potential ATP synthesis. Such regulation will ensure an optimal acid adaption in S. mutans.
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