ArticleEnvironmental health perspectives2010
Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 378 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
378 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,165 citations in OpenAlex.
- Aflatoxin MVeterinary medicine and science · 2026Pooled it
- Systematic review and meta-analysis on the prevalence and concentration of aflatoxin BMycotoxin research · 2025Pooled it
- Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma.Cancer medicine · 2025Pooled it
- Level of exposure to aflatoxins during pregnancy and its association with adverse birth outcomes in Africa: a meta-analysis.International health · 2024Pooled it
- Pooled it
- A pilot evaluation of ChatGPT-4o-assisted hypothesis generation for exploring potential links between fungal biology and cervical cancer.Antonie van Leeuwenhoek · 2026Article
- Aflatoxin-associated hepatocarcinogenesis in a changing climate: the gut microbiome as a missing link in the One Health framework.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Evaluation of commercial maize hybrids for Aspergillus ear rot resistance and aflatoxin accumulation under natural and artificial inoculation conditions.Mycotoxin research · 2026Article
- Article
- Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Aflatoxin BJournal of fungi (Basel, Switzerland) · 2026Article
- Assessment of Aflatoxins and Heavy Metals inFoods (Basel, Switzerland) · 2026Article
- Oxidative Stress in Biotoxin-Induced Liver Injury: From ROS Generation to Cell Death and Therapeutic Intervention.Toxics · 2026Review
- Review
- Mycoflora, mycotoxin exposure and cancer risk assessment inToxicology reports · 2026Article
- Presumptive fatal Aflatoxicosis of dogs in Southern Malawi.Veterinary and animal science · 2026Article
- Cytological Evaluation of Space-Occupying Lesions of the Liver by Fine Needle Aspiration.Cureus · 2026Article
- Aflatoxin B1 and food safety: Mechanisms of action associated to Hepatocellular Carcinoma.Archives of microbiology · 2026Review
- METTL3 inhibition attenuates AFBJournal of animal science and biotechnology · 2026Review
- Biological Detoxification of Mycotoxins by Lactic Acid Bacteria: Safeguarding Food from Fungal Contaminants.Toxins · 2026Review
318 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a known human liver carcinogen.
objectivesWe sought to determine the global burden of HCC attributable to aflatoxin exposure.
methodsWe conducted a quantitative cancer risk assessment, for which we collected global data on food-borne aflatoxin levels, consumption of aflatoxin-contaminated foods, and hepatitis B virus (HBV) prevalence. We calculated the cancer potency of aflatoxin for HBV-postive and HBV-negative individuals, as well as the uncertainty in all variables, to estimate the global burden of aflatoxin-related HCC.
resultsOf the 550,000-600,000 new HCC cases worldwide each year, about 25,200-155,000 may be attributable to aflatoxin exposure. Most cases occur in sub-Saharan Africa, Southeast Asia, and China where populations suffer from both high HBV prevalence and largely uncontrolled aflatoxin exposure in food.
conclusionsAflatoxin may play a causative role in 4.6-28.2% of all global HCC cases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.