Evidence map›Paper›PMID 20172738›Full record

ReviewTrends in endocrinology and metabolism: TEM2010

Cervical remodeling during pregnancy and parturition.

Brenda Timmons, Meredith Akins, Mala Mahendroo

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Methods for assessing pre-induction cervical ripening.The Cochrane database of systematic reviews · 2015
    Pooled it
  2. Pooled it
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  7. Article
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  10. Observational
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  15. VaginalFrontiers in cellular and infection microbiology · 2026
    Article
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  17. Review
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  19. Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Review
  20. Review

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brenda TimmonsDepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9032, USA.
Meredith Akins
Mala Mahendroo

Funding

TRANSCRIPTIONAL REGULATION OF CERVICAL COMPETENCE DURING PREGNANCYP01HD011149 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI MENDELSON, CAROLE R · 1998 to 2015
$17.7M
Molecular Mechanisms of ParturitionR01HD043154 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI MAHENDROO, MALA S. · 2003 to 2010
$2.1M
NICHD NIH HHS P01 HD011149NICHD NIH HHS R01 HD043154PHS HHS P01 11149
6 · The paper itself

Abstract

Appropriate and timely cervical remodeling is key for successful birth. Premature cervical opening can result in preterm birth which occurs in 12.5% of pregnancies. Research focused on the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. This review highlights recent findings that better define molecular processes driving progressive disorganization of the cervical extracellular matrix. This includes studies that redefine the role of immune cells and identify diverse functions of the cervical epithelia and hyaluronan in remodeling. New investigations proposing that infection-induced premature cervical remodeling is distinct from the normal process are presented. Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models.

Indexed as

AnimalsCervical RipeningCervix UteriFemaleHumansLabor Stage, FirstParturitionPregnancy

Identifiers

PMID20172738
PMCPMC2880223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.