Evidence map›Paper›PMID 20172576›Full record

ArticleVirology2010

Glycoprotein gene sequence variation in rhesus monkey rhadinovirus.

Young C Shin, Leandro R Jones, Julieta Manrique, William Lauer, Angela Carville, Keith G Mansfield, Ronald C Desrosiers

Abstract read
In one paragraph

Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Rhesus Monkey Rhadinovirus Isolated from Hemangioma Tissue.Microbiology resource announcements · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Young C ShinNew England Primate Research Center, Harvard Medical School, Southborough, MA 01772-9102, USA.
Leandro R Jones
Julieta Manrique
William Lauer
Angela Carville
Keith G Mansfield
Ronald C Desrosiers

Funding

ZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WESTMORELAND, SUSAN V. · 1985 to 2011
$139.3M
Gamma-2 Herpesviruses as Vaccine Vectors for AIDSR37AI063928 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DESROSIERS, RONALD C · 2013 to 2022
$5.1M
Gamma-2 Herpesviruses as Vaccine Vectors for AIDSR01AI063928 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DESROSIERS, RONALD C · 2005 to 2013
$2.9M
Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and NeutralizationR01AI072004 · NIAID · HARVARD MEDICAL SCHOOL · PI DESROSIERS, RONALD C · 2008 to 2012
$1.9M
Gamma-2 Herpesviruses as Vaccine Vectors for AIDSR56AI063928 · NIAID · HARVARD MEDICAL SCHOOL · PI DESROSIERS, RONALD C · 2012 to 2012
$605k
MOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATIONK26RR000168 · NCRR · OHIO STATE UNIVERSITY · PI ROSOL, THOMAS J · 2000 to 2004
$547k
NCRR NIH HHS K26 RR000168NCRR NIH HHS P51 RR000168NCRR NIH HHS RR00168NIAID NIH HHS AI084698NIAID NIH HHS AI63928NIAID NIH HHS R01 AI063928NIAID NIH HHS R01 AI072004NIAID NIH HHS R37 AI063928NIAID NIH HHS R56 AI063928
6 · The paper itself

Abstract

Gene sequences for seven glycoproteins from 20 independent isolates of rhesus monkey rhadinovirus (RRV) and of the corresponding seven glycoprotein genes from nine strains of the Kaposi's sarcoma-associated herpesvirus (KSHV) were obtained and analyzed. Phylogenetic analysis revealed two discrete groupings of RRV gH sequences, two discrete groupings of RRV gL sequences and two discrete groupings of RRV gB sequences. We called these phylogenetic groupings gH(a), gH(b), gL(a), gL(b), gB(a) and gB(b). gH(a) was always paired with gL(a) and gH(b) was always paired with gL(b) for any individual RRV isolate. Since gH and gL are known to be interacting partners, these results suggest the need of matching sequence types for function of these cooperating proteins. gB phylogenetic grouping was not associated with gH/gL phylogenetic grouping. Our results demonstrate two distinct, distantly-related phylogenetic groupings of gH and gL of RRV despite a remarkable degree of sequence conservation within each individual phylogenetic group.

Indexed as

Polymorphism, GeneticAnimalsCluster AnalysisDNA, ViralGlycoproteinsHerpesviridae InfectionsHerpesvirus 8, HumanHumansMacaca mulattaMolecular Sequence DataMonkey DiseasesPhylogenyRhadinovirusSequence Analysis, DNASequence HomologyTumor Virus InfectionsDNA, ViralGlycoproteinsViral Proteins

Identifiers

PMID20172576
PMCPMC2852144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.