ArticleThe Journal of urology2010
Comprehensive 5-year study of cytogenetic aberrations in 668 infertile men.
Article in The Journal of urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566599 (A Retrospective Review of the Utilization of Preimplantation Genetic Testing for Aneuploidy), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Retrospective Review of the Utilization of Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Clinical diagnostic testing for the cytogenetic and molecular causes of male infertility: the Mayo Clinic experience.Journal of assisted reproduction and genetics · 2011Pooled it
- A Combined Approach: Karyotyping and QF-PCR for Comprehensive Genetic Screening in Male Infertility.Biochemical genetics · 2026Article
- From genes to generations: genetic evaluation and counseling for infertility and pregnancy loss.Frontiers in genetics · 2026Article
- Chromosome defects and male factor infertility.Fertility and sterility · 2025Review
- Article
- Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans.Cell death & disease · 2024Article
- Genomic testing for copy number and single nucleotide variants in spermatogenic failure.Journal of assisted reproduction and genetics · 2022Article
- Reproductive outcomes in individuals with chromosomal reciprocal translocations.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database.Journal of assisted reproduction and genetics · 2021Article
- Copy-number analysis of Y-linked loci in young men with non-obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y.Reproductive medicine and biology · 2020Article
- Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of "big data".Fertility and sterility · 2020Review
- Genetic Landscape of Nonobstructive Azoospermia and New Perspectives for the Clinic.Journal of clinical medicine · 2020Review
- Losing maleness: Somatic Y chromosome loss at every stage of a man's life.FASEB bioAdvances · 2019Article
- Molecular and cytogenetic analysis of infertile Hakka men with azoospermia and severe oligozoospermia in southern China.The Journal of international medical research · 2019Observational
- Chromosomal scan of single sperm cells by combining fluorescence-activated cell sorting and next-generation sequencing.Journal of assisted reproduction and genetics · 2019Article
- Infertility in Patients With Klinefelter Syndrome: Optimal Timing for Sperm and Testicular Tissue Cryopreservation.Reviews in urology · 2018Article
- Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia.The Journal of international medical research · 2018Article
- The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities.Human reproduction update · 2017Review
- Prevalence of chromosomal abnormalities in infertile couples in romania.Balkan journal of medical genetics : BJMG · 2015Article
- Chromosomal abnormalities in patients with oligozoospermia and non-obstructive azoospermia.Journal of assisted reproduction and genetics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe causes of male infertility are heterogeneous but more than 50% of cases have a genetic basis. Specific genetic defects have been identified in less than 20% of infertile males and, thus, most causes remain to be elucidated. The most common cytogenetic defects associated with nonobstructive azoospermia are numerical and structural chromosome abnormalities, including Klinefelter syndrome (47,XXY) and Y chromosome microdeletions. To refine the incidence and nature of chromosomal aberrations in males with infertility we reviewed cytogenetic results in 668 infertile men with oligozoospermia and azoospermia. MATERIALS AND
methodsHigh resolution Giemsa banding chromosome analysis and/or fluorescence in situ hybridization were done in 668 infertile males referred for routine cytogenetic analysis between January 2004 and March 2009.
resultsThe overall incidence of chromosomal abnormalities was about 8.2%. Of the 55 patients with abnormal cytogenetic findings sex chromosome aneuploidies were observed in 29 (53%), including Klinefelter syndrome in 27 (49%). Structural chromosome abnormalities involving autosomes (29%) and sex chromosomes (18%) were detected in 26 infertile men. Abnormal cytogenetic findings were observed in 35 of 264 patients (13.3%) with azoospermia and 19 of 365 (5.2%) with oligozoospermia.
conclusionsStructural chromosomal defects and low level sex chromosome mosaicism are common in oligozoospermia cases. Extensive cytogenetic assessment and fluorescence in situ hybridization may improve the detection rate in males with oligozoospermia. These findings highlight the need for efficient genetic testing in infertile men so that couples may make informed decisions on assisted reproductive technologies to achieve parenthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.