ArticleAnnals of epidemiology2010
Physical activity, cognitive function, and mortality in a US national cohort.
Article in Annals of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis.BMC public health · 2014Pooled it
- Physical activity and cognitive function in individuals over 60 years of age: a systematic review.Clinical interventions in aging · 2014Pooled it
- Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial.Scientific reports · 2020Trial
- ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- ATHLOS Healthy Aging Scale score as the predictor of all-cause mortality in Poland and Czechia.Frontiers in public health · 2023Article
- Assessment of cognitive function among adults aged ≥ 60 years using the Revised Hasegawa Dementia Scale: cross-sectional study, Lao People's Democratic Republic.Health research policy and systems · 2022Article
- Article
- Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017.International journal of environmental research and public health · 2020Article
- Patterns of leisure time and household physical activity and the risk of mortality among middle-aged Korean adults.PloS one · 2020Article
- Article
- Article
- Is there a relationship between accelerometer-assessed physical activity and sedentary behavior and cognitive function in US Hispanic/Latino adults? The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).Preventive medicine · 2017Article
- The Effect of Neurobehavioral Test Performance on the All-Cause Mortality among US Population.BioMed research international · 2016Article
- Patterns of Mortality in the Elderly in Chi Linh, Hai Duong, Vietnam, Period 2004-2012.AIMS public health · 2016Article
- [Physical activity in adult working population: results from the European National Health Survey for Spain (2009)].Atencion primaria · 2015Article
- Physical activity and mortality among middle-aged and older adults in the United States.Journal of physical activity & health · 2014Article
- Investigating terminal decline: results from a UK population-based study of aging.Psychology and aging · 2013Article
- Routine physical activity and mortality in Mexican Americans aged 75 and older.Journal of the American Geriatrics Society · 2012Article
- High-density lipoprotein cholesterol, cognitive function and mortality in a U.S. national cohort.Lipids in health and disease · 2011Article
- The relationship between levels of physical activity, adherence to the MIND diet, and cognitive impairment in adults aged 65 years or older in Pakistan.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeIncreasing physical activity is postulated to slow cognitive decline associated with aging. Low levels of both physical activity and cognitive function are associated with increased risk of mortality. We test the hypothesis that the relative protective effect of high physical activity level as related to mortality is greater in persons with impaired cognitive function than in others.
methodsData were analyzed from a longitudinal mortality follow-up study of 5903 American men and women aged 60 years and older examined in 1988 to 1994 who were followed an average of 8.5 years. Measurements at baseline included self-reported leisure-time physical activity (LTPA), a short index of cognitive function (SICF), sociodemographic data, health status, and physical and biochemical measurements.
resultsDeath during follow-up occurred in 2431 persons. In bivariate cross-sectional analyses, more frequent LTPA was associated with greater cognitive function. In proportional hazards regression analysis, no significant interaction of LTPA with cognitive function was found; however, there was a significant age-LTPA interaction. After adjusting for confounding by baseline sociodemographic data and health status at ages 60 to 74, the hazards ratio (95% confidence intervals) was for LTPA more than 8 times weekly compared with none (0.51; 0.38-0.76, p < .001) and for low SICF score compared with high 1.43 (1.36; 1.00-1.84, p < .05). After controlling for health behaviors, blood pressure, and body mass, C-reactive protein, and high-density lipoprotein cholesterol, the LTPA hazards ratio was 0.52 (0.35-0.78; p = .002), but cognitive function was no longer significant. At ages 75 and older, results were similar for LTPA, but cognitive function remained significant after adjustment.
conclusionsIn a nationwide cohort of older Americans, analyses demonstrated a lower risk of death independent of confounders among those with frequent LTPA. Much of the effect of low cognitive function could be explained by other risk factors at ages 60 to 74 but not 75 years and older.
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