ArticleNeuroImage2010
Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- DNA methylation and brain structure and function across the life course: A systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Uncovering patterns of white matter degeneration in normal aging: Links between morphometry and microstructure.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Sex moderates the association between age and myelin water fraction in the cingulum and fornix among older adults without dementia.Frontiers in aging neuroscience · 2023Article
- Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome.Neurobiology of aging · 2022Article
- Contribution of white matter hyperintensities to ventricular enlargement in older adults.NeuroImage. Clinical · 2022Article
- Hyperexcitability in Aging Is Lost in Alzheimer's: What Is All the Excitement About?Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The effect of network thresholding and weighting on structural brain networks in the UK Biobank.NeuroImage · 2020Article
- Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer's Disease.Current neuropharmacology · 2020Review
- Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age.Frontiers in neurology · 2019Article
- Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.Neurobiology of aging · 2018Article
- Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study.NeuroImage · 2018Article
- Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.Biological psychiatry · 2018Article
- A latent measure explains substantial variance in white matter microstructure across the newborn human brain.Brain structure & function · 2017Article
- Review
- Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.Frontiers in aging neuroscience · 2017Article
- Associations between education and brain structure at age 73 years, adjusted for age 11 IQ.Neurology · 2016Article
- Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?Psychoneuroendocrinology · 2015Article
- Coupled changes in brain white matter microstructure and fluid intelligence in later life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Tract shape modeling detects changes associated with preterm birth and neuroprotective treatment effects.NeuroImage. Clinical · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Quantitative tractography may provide insights into regional heterogeneity of changes in white matter structure in normal ageing. Here we examine how brain atrophy and white matter lesions affect correlations between tract shape, tract integrity and age in a range of frontal and non-frontal tracts in 90 non-demented subjects aged over 65 years using an enhanced version of probabilistic neighbourhood tractography. This novel method for automatic single seed point placement employs unsupervised learning and streamline selection to provide reliable and accurate tract segmentation, whilst also indicating how the shape of an individual tract compares to that of a predefined reference tract. There were significant negative correlations between tract shape similarity to reference tracts derived from a young brain white matter atlas and age in genu and splenium of corpus callosum. Controlling for intracranial and lateral ventricle volume, the latter of which increased significantly with age, attenuated these correlations by 40% and 84%, respectively, indicating that this age-related change in callosal tract topology is significantly mediated by global atrophy and ventricular enlargement. In accordance with the "frontal ageing" hypothesis, there was a significant positive correlation between mean diffusivity (D) and age, and a significant negative correlation between fractional anisotropy (FA) and age in corpus callosum genu; correlations not seen in splenium. Significant positive correlations were also observed between D and age in bilateral cingulum cingulate gyri, uncinate fasciculi and right corticospinal tract. This pattern of correlations was not, however, reproduced when those subjects with significant white matter lesion load were analyzed separately from those without. These data therefore suggest that brain atrophy and white matter lesions play a significant role in driving regional patterns of age-related changes in white matter tract shape and integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.