ReviewNeurobiology of disease2010
Epigenetic changes and non-coding expanded repeats.
Review in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Repeat Expansion and Somatic Instability in TCF4 in Patients With Fuchs Endothelial Corneal Dystrophy Identified by Small Pool PCR.Investigative ophthalmology & visual science · 2025Article
- Review
- Clinical and neuroimaging review of triplet repeat diseases.Japanese journal of radiology · 2023Review
- Blood Transcriptome Profiling Links Immunity to Disease Severity in Myotonic Dystrophy Type 1 (DM1).International journal of molecular sciences · 2022Article
- Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1.Frontiers in neurology · 2019Review
- Polycomb repressive complex 1 provides a molecular explanation for repeat copy number dependency in FSHD muscular dystrophy.Human molecular genetics · 2017Article
- Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability.Scientific reports · 2017Article
- Statistical Enrichment of Epigenetic States Around Triplet Repeats that Can Undergo Expansions.Frontiers in neuroscience · 2016Article
- Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy.Annals of clinical and translational neurology · 2016Article
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.Scientific reports · 2015Article
- Mechanisms of RNA-induced toxicity in CAG repeat disorders.Cell death & disease · 2013Review
- Non-coding RNAs in Alzheimer's disease.Molecular neurobiology · 2013Review
- Friedreich's ataxia, frataxin, PIP5K1B: echo of a distant fracas.Oxidative medicine and cellular longevity · 2013Review
- The origin of genetic instability in CCTG repeats.Nucleic acids research · 2011Article
- Non-coding RNA networks underlying cognitive disorders across the lifespan.Trends in molecular medicine · 2011Review
- The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Human molecular genetics · 2010Article
- Review
- Article
- Diagnosing and Treating Nervous System Disorders by Targeting Novel Classes of Non-coding RNAs.International drug discoveryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many neurogenetic disorders are caused by unstable expansions of tandem repeats. Some of the causal mutations are located in non-protein-coding regions of genes. When pathologically expanded, these repeats can trigger focal epigenetic changes that repress the expression of the mutant allele. When the mutant gene is not repressed, the transcripts containing the expanded repeat can give rise to a toxic gain-of-function by the mutant RNA. These two mechanisms, heterochromatin-mediated gene repression and RNA dominance, produce a wide range of neurodevelopmental and neurodegenerative abnormalities. Here we review the mechanisms of gene dysregulation induced by non-coding repeat expansions, and early indications that some of these disorders may prove to be responsive to therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.