ArticleJournal of the American Society for Mass Spectrometry2010
Comparative dissociation of peptide polyanions by electron impact and photo-induced electron detachment.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- VUV Photodissociation Induced by a Deuterium Lamp in an Ion Trap.Journal of the American Society for Mass Spectrometry · 2019Article
- Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.Mass spectrometry reviews · 2018Review
- Photoelectron Transfer Dissociation Reveals Surprising Favorability of Zwitterionic States in Large Gaseous Peptides and Proteins.Journal of the American Chemical Society · 2017Article
- Sulfur Pentafluoride is a Preferred Reagent Cation for Negative Electron Transfer Dissociation.Journal of the American Society for Mass Spectrometry · 2017Article
- 213 nm Ultraviolet Photodissociation on Peptide Anions: Radical-Directed Fragmentation Patterns.Journal of the American Society for Mass Spectrometry · 2016Article
- Ion Activation Methods for Peptides and Proteins.Analytical chemistry · 2016Review
- UV photodissociation of proline-containing peptide ions: insights from molecular dynamics.Journal of the American Society for Mass Spectrometry · 2015Article
- Photodissociation mass spectrometry: new tools for characterization of biological molecules.Chemical Society reviews · 2014Review
- Concurrent automated sequencing of the glycan and peptide portions of O-linked glycopeptide anions by ultraviolet photodissociation mass spectrometry.Analytical chemistry · 2013Article
- High-throughput database search and large-scale negative polarity liquid chromatography-tandem mass spectrometry with ultraviolet photodissociation for complex proteomic samples.Molecular & cellular proteomics : MCP · 2013Article
- Systematic comparison of ultraviolet photodissociation and electron transfer dissociation for peptide anion characterization.Journal of the American Society for Mass Spectrometry · 2012Article
- Tyrosine deprotonation yields abundant and selective backbone cleavage in peptide anions upon negative electron transfer dissociation and ultraviolet photodissociation.Journal of the American Chemical Society · 2012Article
- Characterizing peptide neutral losses induced by negative electron-transfer dissociation (NETD).Journal of the American Society for Mass Spectrometry · 2012Article
- Analysis of the acidic proteome with negative electron-transfer dissociation mass spectrometry.Analytical chemistry · 2012Article
- Formation and fragmentation of radical peptide anions: insights from vacuum ultra violet spectroscopy.Journal of the American Society for Mass Spectrometry · 2012Article
- Electron detachment dissociation for top-down mass spectrometry of acidic proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- 193-nm photodissociation of singly and multiply charged peptide anions for acidic proteome characterization.Proteomics · 2011Article
- Shedding light on the frontier of photodissociation.Journal of the American Society for Mass Spectrometry · 2011Article
- Photoinduced dissociation of heparin-derived oligosaccharides controlled by charge location.Journal of the American Society for Mass Spectrometry · 2010Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compare product-ion mass spectra produced by electron detachment dissociation (EDD) and electron photodetachment dissociation (EPD) of multi-deprotonated peptides on a Fourier transform and a linear ion trap mass spectrometer, respectively. Both methods, EDD and EPD, involve the electron emission-induced formation of a radical oxidized species from a multi-deprotonated precursor peptide. Product-ion mass spectra display mainly fragment ions resulting from backbone cleavages of C(alpha)-C bond ruptures yielding a and x ions. Fragment ions originating from N-C(alpha) backbone bond cleavages are also observed, in particular by EPD. Although EDD and EPD methods involve the generation of a charge-reduced radical anion intermediate by electron emission, the product ion abundance distributions are drastically different. Both processes seem to be triggered by the location and the recombination of radicals (both neutral and cation radicals). Therefore, EPD product ions are predominantly formed near tryptophan and histidine residues, whereas in EDD the negative charge solvation sites on the backbone seem to be the most favorable for the nearby bond dissociation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.