ArticleJournal of the American Society for Mass Spectrometry2010
Charge remote fragmentation in electron capture and electron transfer dissociation.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Distinguishing Ile/Leu Variant Ligands in the Immunopeptidome Using Hybrid EAD + CID Fragmentation (ExCID).Analytical chemistry · 2026Article
- Direct and Detailed Site-Specific Glycopeptide Characterization by Higher-Energy Electron-Activated Dissociation Tandem Mass Spectrometry.Analytical chemistry · 2024Article
- Top-down mass spectrometry of intact phosphorylated β-casein: Correlation between the precursor charge state and internal fragments.Journal of mass spectrometry : JMS · 2019Article
- w-Type ions formed by electron transfer dissociation of Cys-containing peptides investigated by infrared ion spectroscopy.Journal of mass spectrometry : JMS · 2018Article
- Large-Scale Differentiation and Site Specific Discrimination of Hydroxyproline Isomers by Electron Transfer/Higher-Energy Collision Dissociation (EThcD) Mass Spectrometry.Analytical chemistry · 2018Article
- An EThcD-Based Method for Discrimination of Leucine and Isoleucine Residues in Tryptic Peptides.Journal of the American Society for Mass Spectrometry · 2017Article
- Algorithms and design strategies towards automated glycoproteomics analysis.Mass spectrometry reviews · 2017Review
- Study of Ion Dynamics by Electron Transfer Dissociation: Alkali Metals as Targets.Mass spectrometry (Tokyo, Japan) · 2017Article
- Structural identification of electron transfer dissociation products in mass spectrometry using infrared ion spectroscopy.Nature communications · 2016Article
- Competitive Hydrogen Atom Migrations Accompanying Cascade Dissociations of Peptide Cation-Radicals of theInternational journal of mass spectrometry · 2015Article
- Mechanistic study on electron capture dissociation of the oligosaccharide-Mg²⁺ complex.Journal of the American Society for Mass Spectrometry · 2014Article
- Electron capture dissociation studies of the fragmentation patterns of doubly protonated and mixed protonated-sodiated peptoids.Journal of the American Society for Mass Spectrometry · 2014Article
- Direct detection of S-palmitoylation by mass spectrometry.Analytical chemistry · 2013Article
- Light-induced conversion of Trp to Gly and Gly hydroperoxide in IgG1.Molecular pharmaceutics · 2013Article
- Does Electron Capture Dissociation Cleave Protein Disulfide Bonds?ChemistryOpen · 2012Article
- Characterizing peptide neutral losses induced by negative electron-transfer dissociation (NETD).Journal of the American Society for Mass Spectrometry · 2012Article
- Gas-phase fragmentation of [M+nH+OH]n•+ ions formed from peptides containing intra-molecular disulfide bonds.Journal of the American Society for Mass Spectrometry · 2011Article
- Topoisomer differentiation of molecular knots by FTICR MS: lessons from class II lasso peptides.Journal of the American Society for Mass Spectrometry · 2011Article
- Unusual fragmentation of β-linked peptides by ExD tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
- Structural heterogeneity of doubly-charged peptide b-ions.Journal of the American Society for Mass Spectrometry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Secondary fragmentations of three synthetic peptides (human alphaA crystallin peptide 1-11, the deamidated form of human betaB2 crystallin peptide 4-14, and amyloid beta peptide 25-35) were studied in both electron capture dissociation (ECD) and electron-transfer dissociation (ETD) mode. In ECD, in addition to c and z. ion formations, charge remote fragmentations (CRF) of z. ions were abundant, resulting in internal fragment formation or partial/entire side-chain losses from amino acids, sometimes several residues away from the backbone cleavage site, and to some extent multiple side-chain losses. The internal fragments were observed in peptides with basic residues located in the middle of the sequences, which was different from most tryptic peptides with basic residues located at the C-terminus. These secondary cleavages were initiated by hydrogen abstraction at the alpha-, beta-, or gamma-position of the amino acid side chain. In comparison, ETD generates fewer CRF fragments than ECD. This secondary cleavage study will facilitate ECD/ETD spectra interpretation, and help de novo sequencing and database searching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.