ReviewRespiratory physiology & neurobiology2010
State-dependent central chemoreception: a role of orexin.
Review in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Hypothalamic Glutamatergic/Orexinergic Neurons Attenuate Fentanyl-Induced Respiratory Depression via Medullary Pre-BöTzinger Complex Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Quantifying ventilatory control with 3% CO2 inhalation during exercise.Frontiers in physiology · 2025Article
- COBrain structure & function · 2022Article
- Body composition and obstructive sleep apnoea assessment in adult patients with Prader-Willi syndrome: a case control study.Journal of endocrinological investigation · 2022Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
- Article
- Hypercapnia-induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats.The Journal of physiology · 2018Article
- Orexin and Central Modulation of Cardiovascular and Respiratory Function.Current topics in behavioral neurosciences · 2017Review
- An augmented CO2 chemoreflex and overactive orexin system are linked with hypertension in young and adult spontaneously hypertensive rats.The Journal of physiology · 2016Article
- Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control.Physiology & behavior · 2013Review
- Antagonism of orexin receptors in the posterior hypothalamus reduces hypoglossal and cardiorespiratory excitation from the perifornical hypothalamus.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- The brain orexin system and almorexant in fear-conditioned startle reactions in the rat.Psychopharmacology · 2012Article
- State-dependent modulation of breathing in urethane-anesthetized rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Computational models and emergent properties of respiratory neural networks.Comprehensive Physiology · 2012Review
- Respiratory regulation in narcolepsy.Sleep & breathing = Schlaf & Atmung · 2012Article
- Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.PloS one · 2012Article
- Respiration and autonomic regulation and orexin.Progress in brain research · 2012Review
- Central chemoreceptors: locations and functions.Comprehensive Physiology · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Sites involved in central chemoreception (CCR) are widely distributed in the brain. One possible explanation for the existence of multiple central chemoreceptor sites is the vigilance state-dependent hypothesis, that some sites are of greater importance in wakefulness others in sleep. We briefly summarize the evidence for a distributed network of central chemoreceptor sites and a vigilance state-dependent differentiation among them. We then discuss the role of orexin in vigilance state-dependent CCR based on our recent studies using orexin knockout mice and focal microdialysis of an orexin receptor antagonist at the retrotrapezoid nucleus and medullary raphe in rats. Orexin affects CCR in a vigilance state-dependent manner that varies with circadian time. Orexin also contributes to emotional stress- and other state-dependent related regulation of ventilation, e.g., the defense response. Diversity in central chemoreception including orexin neurons and the synaptic control of respiratory and cardiovascular output neurons appears to be necessary for animals to adapt themselves to constantly changing situations and behavioral states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.