Evidence map›Paper›PMID 20170686›Full record

ReviewBehavioural brain research2011

Regulation of cortical acetylcholine release: insights from in vivo microdialysis studies.

Jim R Fadel

Abstract readReview
In one paragraph

Review in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Free energy, precision and learning: the role of cholinergic neuromodulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Trial
  2. Article
  3. Article
  4. The Central Cholinergic Synapse: A Primer.International journal of molecular sciences · 2025
    Review
  5. Cholinergic Mechanisms in Gastrointestinal Neoplasia.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jim R FadelDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, USA. jim.fadel@uscmed.sc.edu

Funding

Aging, acetylcholine and the hypothalamusR01AG030646 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FADEL, JIM R · 2008 to 2011
$1.2M
NIA NIH HHS R01 AG030646
6 · The paper itself

Abstract

Acetylcholine release links the activity of presynaptic neurons with their postsynaptic targets and thus represents the intercellular correlate of cholinergic neurotransmission. Here, we review the regulation and functional significance of acetylcholine release in the mammalian cerebral cortex, with a particular emphasis on information derived from in vivo microdialysis studies over the past three decades. This information is integrated with anatomical and behavioral data to derive conclusions regarding the role of cortical cholinergic transmission in normal behavioral and how its dysregulation may contribute to cognitive correlates of several neuropsychiatric conditions. Some unresolved issues regarding the regulation and significance of cortical acetylcholine release and the promise of new methodology for advancing our knowledge in this area are also briefly discussed.

Indexed as

AcetylcholineAgingAnimalsCentral Nervous System StimulantsCerebral CortexCholinergic FibersCognitionHumansMental DisordersMicrodialysisModels, NeurologicalNeural PathwaysPresynaptic TerminalsProsencephalonSynaptic TransmissionAcetylcholineCentral Nervous System Stimulants

Identifiers

PMID20170686
PMCPMC2925059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.