ArticleVirology journal2010
The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments.
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections.Virology journal · 2020Article
- Association of the Polymorphism of rs1799822 on Carnitine Palmitoyltransferase II Gene with Severe Enterovirus 71 Encephalitis in Chinese Children.Journal of molecular neuroscience : MN · 2019Article
- Sophocarpine against enterovirus 71Experimental and therapeutic medicine · 2017Article
- Coxsackie B3/B4-Related Acute Flaccid Myelitis.Neurocritical care · 2017Article
- Protective effect of enterovirus‑71 (EV71) virus‑like particle vaccine against lethal EV71 infection in a neonatal mouse model.Molecular medicine reports · 2015Article
- Article
- Coxsackievirus B4 myocarditis and meningoencephalitis in newborn twins.Neuropathology : official journal of the Japanese Society of Neuropathology · 2014Article
- Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection.Virology journal · 2013Article
- Article
- A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor.Virology journal · 2012Article
- Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications.Virology journal · 2012Article
- Protection against enterovirus 71 with neutralizing epitope incorporation within adenovirus type 3 hexon.PloS one · 2012Article
- Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication.Virology journal · 2011Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEV71 occasionally cause a series of severe neurological symptoms, including aseptic meningitis, encephalitis, and poliomyelitis-like paralysis. However, the neurological destruction mechanism was remained to be clarified. This study described the cross reaction between EV71 induced IgG and human brain tissue.
resultsCross reaction of the IgG from 30 EV71 infected patients' sera to human tissues of cerebra was observed, which suggested that some EV71 antigens could induce IgG cross-reactivity to human cerebra. To identify the regions of EV71 virus that containing above antigens, the polypeptide of virus was divided into 19 peptides by expression in prokaryotes cell. Mouse anti-sera of these peptides was prepared and applied in immunohistochemical staining with human adult and fetus brain tissue, respectively. The result indicated the 19 peptides can be classified into three groups: strong cross-reactivity, weak cross-reactivity and no cross-reactivity with human brain tissue according the cross reaction activity. Then, the increased Blood Brain Barrier (BBB) permeability and permits IgG entry in neonatal mice after EV71 infection was determined.
conclusionEV71 induced IgG could enter BBB and cross-reacted with brain tissue in EV71 infected neonatal mice, and then the peptides of EV71 that could induce cross-reactivity with brain tissue were identified, which should be avoided in future vaccine designing.
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