ArticleJournal of neuroengineering and rehabilitation2010
Transmembrane potential induced on the internal organelle by a time-varying magnetic field: a model study.
Article in Journal of neuroengineering and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Restore axonal conductance in a locally demyelinated axon with electromagnetic stimulation.Journal of neural engineering · 2025Article
- Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024Review
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Application of the Taguchi method to explore a robust condition of tumor-treating field treatment.PloS one · 2022Article
- Finding the Location of Axonal Activation by a Miniature Magnetic Coil.Frontiers in computational neuroscience · 2022Article
- Irreversible Electroporation: Background, Theory, and Review of Recent Developments in Clinical Oncology.Bioelectricity · 2019Review
- Neuromodulation with electromagnetic stimulation for seizure suppression: From electrode to magnetic coil.IBRO reports · 2019Review
- Changes in Global and Nodal Networks in Patients With Unipolar Depression After 3-Week Repeated Transcranial Magnetic Stimulation Treatment.Frontiers in psychiatry · 2019Article
- Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation.PeerJ · 2018Article
- Biomechanics of cell membrane under low-frequency time-varying magnetic field: a shell model.Medical & biological engineering & computing · 2016Article
- Modeling of Transmembrane Potential in Realistic Multicellular Structures before Electroporation.Biophysical journal · 2016Article
- Neuron matters: electric activation of neuronal tissue is dependent on the interaction between the neuron and the electric field.Journal of neuroengineering and rehabilitation · 2015Review
- Vesicle biomechanics in a time-varying magnetic field.BMC biophysics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhen a cell is exposed to a time-varying magnetic field, this leads to an induced voltage on the cytoplasmic membrane, as well as on the membranes of the internal organelles, such as mitochondria. These potential changes in the organelles could have a significant impact on their functionality. However, a quantitative analysis on the magnetically-induced membrane potential on the internal organelles has not been performed.
methodsUsing a two-shell model, we provided the first analytical solution for the transmembrane potential in the organelle membrane induced by a time-varying magnetic field. We then analyzed factors that impact on the polarization of the organelle, including the frequency of the magnetic field, the presence of the outer cytoplasmic membrane, and electrical and geometrical parameters of the cytoplasmic membrane and the organelle membrane.
resultsThe amount of polarization in the organelle was less than its counterpart in the cytoplasmic membrane. This was largely due to the presence of the cell membrane, which "shielded" the internal organelle from excessive polarization by the field. Organelle polarization was largely dependent on the frequency of the magnetic field, and its polarization was not significant under the low frequency band used for transcranial magnetic stimulation (TMS). Both the properties of the cytoplasmic and the organelle membranes affect the polarization of the internal organelle in a frequency-dependent manner.
conclusionsThe work provided a theoretical framework and insights into factors affecting mitochondrial function under time-varying magnetic stimulation, and provided evidence that TMS does not affect normal mitochondrial functionality by altering its membrane potential.
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