ArticleTobacco induced diseases2010
Destructive effects of smoking on molecular and genetic factors of periodontal disease.
Article in Tobacco induced diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Causal assessment of smoking and tooth loss: a systematic review of observational studies.BMC public health · 2011Pooled it
- Oral Health Effects Among Adults Switching from Cigarettes to on!® Nicotine Pouches Compared to Those Who Continue Smoking.Oral health & preventive dentistry · 2025Trial
- The Relationship of HbA1c Serum Levels with the Severity of Periodontal Disease in Patients with Type 1 Diabetes Mellitus: A Cross-Sectional Study.European journal of dentistry · 2025Article
- Article
- Salivary IL-17 and IL-10 as Potential Diagnostic Biomarkers of Different Stages of Periodontitis in Smoker and Nonsmoker Patients.European journal of dentistry · 2024Article
- The effect of different cigarette smoking levels on gingival crevicular fluid volume and periodontal clinical parameters in Saudi Arabia.The Saudi dental journal · 2023Article
- Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review).Biomedical reports · 2021Review
- Smoking and periodontal microorganisms.The Japanese dental science review · 2019Review
- Influence of Cigarette Smoke Inhalation on an Autogenous Onlay Bone Graft Area in Rats with Estrogen Deficiency: A Histomorphometric and Immunohistochemistry Study.International journal of molecular sciences · 2019Article
- Microbiological and biochemical findings in relation to clinical periodontal status in active smokers, non-smokers and passive smokers.Tobacco induced diseases · 2019Article
- The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers.BMC genomics · 2017Article
- Relationship between salivary stress biomarker levels and cigarette smoking in healthy young adults: an exploratory analysis.Tobacco induced diseases · 2016Article
- Polymorphisms in Glutathione S-Transferase M1, T1, and P1 in Patients with Chronic Periodontitis: A Pilot Study.International scholarly research notices · 2014Article
- Assessment of some biochemical oxidative stress markers in male smokers with chronic periodontitis.Indian journal of clinical biochemistry : IJCB · 2013Article
- Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis.Journal of periodontal & implant science · 2013Article
- Menthol-enhanced cytotoxicity of cigarette smoke demonstrated in two bioassay models.Tobacco induced diseases · 2013Article
- Cognitive function and number of teeth in a community-dwelling population in Japan.Annals of general psychiatry · 2013Article
- The role of tobacco use on dental care and oral disease severity within community dental clinics in Japan.Tobacco induced diseases · 2013Article
- Clinical profile of orofacial infections: an experience from two primary care dental practices.Medicina oral, patologia oral y cirugia bucal · 2012Article
- Anabolic Actions of the Regenerative Agent Enamel Matrix Derivative (EMD) in Oral Periosteal Fibroblasts and MG 63 Osteoblasts, Modulation by Nicotine and Glutathione in a Redox Environment.Journal of functional biomaterials · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many epidemiological evidences have proven the association between smoking and periodontal disease. The causality can be further established by linking findings of traditional epidemiological studies with the developments in molecular techniques that occurred in the last decade. The present article reviews recent studies that address the effect of smoking on molecular and genetic factors in periodontal disease. Most findings support the fact that tobacco smoking modulates destruction of the periodontium through different pathways: microcirculatory and host immune systems, connective tissue, and bone metabolism. Although smokers experience an increased burden of inflammatory responses to microbial challenges compared to non-smokers, understanding the association between smoking and periodontal diseases involves substantial problems with respect to accuracy of measurements, and particularly, sampling of many subjects. It remains unclear whether genetic susceptibility to periodontal disease is influenced by exposure to smoking or the effect of smoking on periodontal disease is influenced by genetic susceptibility. Employment of molecular techniques may play a key role in further elucidation of mechanisms linking smoking and periodontal destruction, the direct relationship as environmental factors and indirect relationship through genetic factors.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.