ArticleTissue engineering. Part C, Methods2010
A novel flow bioreactor for in vitro microvascularization.
Article in Tissue engineering. Part C, Methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Enhancing Viability in Static and Perfused 3D Tissue Constructs Using Sacrificial Gelatin Microparticles.ACS biomaterials science & engineering · 2025Article
- Vessel graft fabricated by the on-site differentiation of human mesenchymal stem cells towards vascular cells on vascular extracellular matrix scaffold under mechanical stimulation in a rotary bioreactor.Journal of materials chemistry. B · 2019Article
- Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Multi-flow channel bioreactor enables real-time monitoring of cellular dynamics in 3D engineered tissue.Communications biology · 2019Article
- Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.Cell transplantation · 2017Article
- Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.Advanced healthcare materials · 2016Article
- Biologically Inspired Smart Release System Based on 3D Bioprinted Perfused Scaffold for Vascularized Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Three-Dimensional Modelling inside a Differential Pressure Laminar Flow Bioreactor Filled with Porous Media.BioMed research international · 2015Article
- Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.Biomaterials · 2015Article
- Flow perfusion co-culture of human mesenchymal stem cells and endothelial cells on biodegradable polymer scaffolds.Annals of biomedical engineering · 2014Article
- Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding.Journal of the Royal Society, Interface · 2014Review
- Procedure for the development of multi-depth circular cross-sectional endothelialized microchannels-on-a-chip.Journal of visualized experiments : JoVE · 2013Article
- Sustainable three-dimensional tissue model of human adipose tissue.Tissue engineering. Part C, Methods · 2013Article
- A differential pressure laminar flow reactor supports osteogenic differentiation and extracellular matrix formation from adipose mesenchymal stem cells in a macroporous ceramic scaffold.BioResearch open access · 2012Article
- Toward an in vitro vasculature: differentiation of mesenchymal stromal cells within an endothelial cell-seeded modular construct in a microfluidic flow chamber.Tissue engineering. Part A · 2012Article
- Simultaneous application of interstitial flow and cyclic mechanical strain to a three-dimensional cell-seeded hydrogel.Tissue engineering. Part C, Methods · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Although the importance of fluid flow for proper vascular development and function in vivo is well recognized, microvascular formation in response to flow has not been well evaluated in a three-dimensional (3D) environment in vitro. In this study, we developed a novel 3D in vitro perfusion system that allows direct investigation of the effects of shear stress on the development of microvasculature in vitro. This system utilizes a 3D collagen gel for suspension of vascular cells and mesenchymal stem cells, through which flow is directly perfused. We characterized the flow conditions and demonstrate the impact of flow on the development of microvasculature using a coculture of endothelial cells and mesenchymal stem cells. With the unique ability to apply bulk flow through the collagen gels, and to estimate shear stress within the constructs, this perfusion system provides a flexible platform for developing a controllable biomimetic environment that can be adapted for a variety of investigations of microvascularization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.