ArticleBiomechanics and modeling in mechanobiology2010
Biomimetic bone mechanotransduction modeling in neonatal rat femur organ cultures: structural verification of proof of concept.
Article in Biomechanics and modeling in mechanobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Micromechanical Loading Studies in Ex Vivo Cultured Embryonic Rat Bones Enabled by a Newly Developed Portable Loading Device.Annals of biomedical engineering · 2023Article
- CAM Model: Intriguing Natural Bioreactor for Sustainable Research and Reliable/Versatile Testing.Biology · 2023Review
- Axial mechanical loading toBone reports · 2021Article
- Ex vivo Bone Models and Their Potential in Preclinical Evaluation.Current osteoporosis reports · 2021Review
- Detection of the Strains Induced in Murine Tibias by Ex Vivo Uniaxial Loading with Different Sensors.Sensors (Basel, Switzerland) · 2019Article
- MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- A novel approach for studying the temporal modulation of embryonic skeletal development using organotypic bone cultures and microcomputed tomography.Tissue engineering. Part C, Methods · 2012Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The goal of this work was to develop and validate a whole bone organ culture model to be utilized in biomimetic mechanotransduction research. Femurs harvested from 2-day-old neonatal rat pups were maintained in culture for 1 week post-harvest and assessed for growth and viability. For stimulation studies, femurs were physiologically stimulated for 350 cycles 24 h post-harvest then maintained in culture for 1 week at which time structural tests were conducted. Comparing 1 and 8 days in culture, bones grew significantly in size over the 7-day culture period. In addition, histology supported adequate diffusion and organ viability at 2 weeks in culture. For stimulation studies, 350 cycles of physiologic loading 24 h post-harvest resulted in increased bone strength over the 7-day culture period. In this work, structural proof of concept was established for the use of whole bone organ cultures as mechanotransduction models. Specifically, this work established that these cultures grow and remain viable in culture, are adequately nourished via diffusion and are capable of responding to a brief bout of mechanical stimulation with an increase in strength.
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