ArticleEuropean archives of psychiatry and clinical neuroscience2010
Patients with schizophrenia show deficits of working memory maintenance components in circuit-specific tasks.
Article in European archives of psychiatry and clinical neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Memory in Psychiatric Disorders: A Review.Life (Basel, Switzerland) · 2025Review
- Gene Variant Related Neurological and Molecular Biomarkers Predict Psychosis Progression, with Potential for Monitoring and Prevention.International journal of molecular sciences · 2024Article
- Repetitive Transcranial Magnetic Stimulation for Working Memory Deficits in Schizophrenia: A Systematic Review of Randomized Controlled Trials.Neuropsychiatric disease and treatment · 2024Review
- Cognitive Dysfunction and Prefrontal Cortical Circuit Alterations in Schizophrenia: Developmental Trajectories.Biological psychiatry · 2022Review
- Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis.Biomarker research · 2015Article
- Clinical significance of knowledge about the structure, function, and impairments of working memory.Medical science monitor : international medical journal of experimental and clinical research · 2013Review
- Single-subject classification of schizophrenia using event-related potentials obtained during auditory and visual oddball paradigms.European archives of psychiatry and clinical neuroscience · 2013Article
- Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning.European archives of psychiatry and clinical neuroscience · 2012Article
- Intracellular monocytic cytokine levels in schizophrenia show an alteration of IL-6.European archives of psychiatry and clinical neuroscience · 2012Article
- Cognitive functioning in severe psychiatric disorders: a general population study.European archives of psychiatry and clinical neuroscience · 2011Article
- A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression.European archives of psychiatry and clinical neuroscience · 2011Article
- The role of the cerebellum in schizophrenia: from cognition to molecular pathways.Clinics (Sao Paulo, Brazil) · 2011Review
- Biomarkers, population-based studies and a proof of principle investigation in pharmacotherapy.European archives of psychiatry and clinical neuroscience · 2010Article
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Authors and funding
4 authors.
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Abstract
Working memory (WM) deficits are a neuropsychological core finding in patients with schizophrenia and also supposed to be a potential endophenotype of schizophrenia. Yet, there is a large heterogeneity between different WM tasks which is partly due to the lack of process specificity of the tasks applied. Therefore, we investigated WM functioning in patients with schizophrenia using process- and circuit-specific tasks. Thirty-one patients with schizophrenia and 47 controls were tested with respect to different aspects of verbal and visuospatial working memory using modified Sternberg paradigms in a computer-based behavioural experiment. Total group analysis revealed significant impairment of patients with schizophrenia in each of the tested WM components. Furthermore, we were able to identify subgroups of patients showing different patterns of selective deficits. Patients with schizophrenia exhibit specific and, in part, selective WM deficits with indirect but conclusive evidence of dysfunctions of the underlying neural networks. These deficits are present in tasks requiring only maintenance of verbal or visuospatial information. In contrast to a seemingly global working memory deficit, individual analysis revealed differential patterns of working memory impairments in patients with schizophrenia.
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