ArticlePloS one2010
IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- The Pleiotropic IL-9 Network in Asthma Pathogenesis and Targeted Therapy.Journal of inflammation research · 2026Review
- Identification of bronchial epithelial genes associated with type 2 eosinophilic inflammation in asthma.The Journal of allergy and clinical immunology · 2025Article
- Interleukin-9 promotes EMT-mediated PMArchives of toxicology · 2024Article
- The Differentially Expressed Genes Responsible for the Development of T Helper 9 Cells From T Helper 2 Cells in Various Disease States: Immuno-Interactomics Study.JMIR bioinformatics and biotechnology · 2023Article
- Development of Adaptive Immunity and Its Role in Lung Remodeling.Advances in experimental medicine and biology · 2023Article
- Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3Frontiers in immunology · 2019Article
- MicroRNA-590-5p represses proliferation of human fetal airway smooth muscle cells by targeting signal transducer and activator of transcription 3.Archives of medical science : AMS · 2018Article
- A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa.PLoS genetics · 2017Article
- Th9 and other IL-9-producing cells in allergic asthma.Seminars in immunopathology · 2017Review
- A deleterious role for Th9/IL-9 in hepatic fibrogenesis.Scientific reports · 2016Article
- IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection.Cellular and molecular gastroenterology and hepatology · 2015Article
- The Complex Role of STAT3 in Viral Infections.Journal of immunology research · 2015Review
- Tailored immune responses: novel effector helper T cell subsets in protective immunity.PLoS pathogens · 2014Review
- Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Th9 cells promote antitumor immune responses in vivo.The Journal of clinical investigation · 2012Article
- Review
- Does airway smooth muscle express an inflammatory phenotype in asthma?British journal of pharmacology · 2011Review
- A brief history of IL-9.Journal of immunology (Baltimore, Md. : 1950) · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPrevious findings support the concept that IL-9 may play a significant role in mediating both pro-inflammatory and changes in airway responsiveness that characterizes the atopic asthmatic state. We previously demonstrated that human airway smooth muscle (ASM) cells express a functional IL-9R that mediate CCL11 expression. However, the signaling pathway governing this effect is not well understood. METHODOLOGY/PRINCIPAL
findingsIn this study, we showed that IL-9 mediated CCL11 expression in ASM cells does not rely on STAT6 or STAT5 but on STAT3 pathway. IL-9 induced rapid STAT3 activation in primary ASM cells that was not observed in case of STAT6 or STAT5. STAT3 binding to CCL11 promoter was also observed in vivo upon IL-9 stimulation of ASM cells. Disruption of STAT3 activity with SH2 domain binding inhibitory peptide results in significant reduction of IL-9 mediated CCL11 promoter activity. DN STAT3beta over-expression in ASM cells, but not Ser 727 STAT3 or STAT6 DN, abolishes IL-9 mediated CCL11 promoter activity. Finally, STAT3 but not STAT6 silenced ASM cells showed significant reduction in IL-9 mediated CCL11 promoter activity and mRNA expression. CONCLUSION/SIGNIFICANCE: Taken together, our results indicate that IL-9 mediated CCL11 via STAT3 signalling pathway may play a crucial role in airway inflammatory responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.