ArticlePLoS pathogens2010
A novel pseudopodial component of the dendritic cell anti-fungal response: the fungipod.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Model systems for optical trapping: the physical basis and biological applications.Biophysical reviews · 2021Review
- Dectin-1-Mediated DC-SIGN Recruitment toLife (Basel, Switzerland) · 2021Article
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Role of Protein Mannosylation in theFrontiers in microbiology · 2019Article
- The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors.Frontiers in immunology · 2018Review
- Doxorubicin Hydrochloride Loaded Zymosan-Polyethylenimine Biopolymeric Nanoparticles for Dual 'Chemoimmunotherapeutic' Intervention in Breast Cancer.Pharmaceutical research · 2017Article
- Specific Human and Candida Cellular Interactions Lead to Controlled or Persistent Infection Outcomes during Granuloma-Like Formation.Infection and immunity · 2017Article
- Review
- Silenced suppressor of cytokine signaling 1 (SOCS1) enhances the maturation and antifungal immunity of dendritic cells in response to Candida albicans in vitro.Immunologic research · 2015Article
- Novel insights into host-fungal pathogen interactions derived from live-cell imaging.Seminars in immunopathology · 2015Review
- Article
- The role of pattern recognition receptors in the innate recognition of Candida albicans.Virulence · 2015Review
- Super-resolution imaging of C-type lectin spatial rearrangement within the dendritic cell plasma membrane at fungal microbe contact sites.Frontiers in physics · 2014Article
- A new tool to quantify receptor recruitment to cell contact sites during host-pathogen interaction.PLoS computational biology · 2014Article
- Article
- The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils.Cellular microbiology · 2013Article
- Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting.Expert review of anti-infective therapy · 2012Review
- Dendritic cells in antifungal immunity and vaccine design.Cell host & microbe · 2012Review
- DC-SIGN and influenza hemagglutinin dynamics in plasma membrane microdomains are markedly different.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fungal pathologies are seen in immunocompromised and healthy humans. C-type lectins expressed on immature dendritic cells (DC) recognize fungi. We report a novel dorsal pseudopodial protrusion, the "fungipod", formed by DC after contact with yeast cell walls. These structures have a convoluted cell-proximal end and a smooth distal end. They persist for hours, exhibit noticeable growth and total 13.7+/-5.6 microm long and 1.8+/-0.67 microm wide at the contact. Fungipods contain clathrin and an actin core surrounded by a sheath of cortactin. The actin cytoskeleton, but not microtubules, is required for fungipod integrity and growth. An apparent rearward flow (225+/-55 nm/second) exists from the zymosan contact site into the distal fungipod. The phagocytic receptor Dectin-1 is not required for fungipod formation, but CD206 (Mannose Receptor) is the generative receptor for these protrusions. The human pathogen Candida parapsilosis induces DC fungipod formation strongly, but the response is species specific since the related fungal pathogens Candida tropicalis and Candida albicans induce very few and no fungipods, respectively. Our findings show that fungipods are dynamic actin-driven cellular structures involved in fungal recognition by DC. They may promote yeast particle phagocytosis by DC and are a specific response to large (i.e., 5 microm) particulate ligands. Our work also highlights the importance of this novel protrusive structure to innate immune recognition of medically significant Candida yeasts in a species specific fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.