Evidence map›Paper›PMID 20168297›Full record

ReviewNature reviews. Genetics2010

Mammalian recombination hot spots: properties, control and evolution.

Kenneth Paigen, Petko Petkov

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 234 citations in OpenAlex.

  1. Article
  2. On the origin of PRDM9-guided recombination hotspots.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Sex differences in crossover interference in house mice.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. A pedigree-based map of crossovers and non-crossovers in aye-ayes (bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kenneth PaigenThe Jackson Laboratory, Bar Harbor, Maine 04609, USA. ken.paigen@jax.org
Petko Petkov
Jackson Laboratory · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
UNC and PERLEGEN, IncP50GM076468 · NIGMS · JACKSON LABORATORY · PI PETKOV, PETKO M · 2006 to 2015
$31.0M
Sex-Specific Regulation of Meiotic Recombination HotspotsR01GM078452 · NIGMS · JACKSON LABORATORY · PI PETKOV, PETKO M · 2007 to 2015
$3.3M
Genomic Organization of Recombination Hot SpotsR01GM078643 · NIGMS · JACKSON LABORATORY · PI PAIGEN, KENNETH · 2006 to 2014
$2.7M
Transacting Genes Regulating Recombination Hotspot ActivitiesR01GM083408 · NIGMS · JACKSON LABORATORY · PI PAIGEN, KENNETH · 2008 to 2014
$2.2M
NCI NIH HHS CA34196NCI NIH HHS P30 CA034196NIGMS NIH HHS GM076468NIGMS NIH HHS GM078452NIGMS NIH HHS GM078643NIGMS NIH HHS GM083408NIGMS NIH HHS P50 GM076468NIGMS NIH HHS R01 GM078452NIGMS NIH HHS R01 GM078643NIGMS NIH HHS R01 GM083408
6 · The paper itself

Abstract

Recombination, together with mutation, generates the raw material of evolution, is essential for reproduction and lies at the heart of all genetic analysis. Recent advances in our ability to construct genome-scale, high-resolution recombination maps and new molecular techniques for analysing recombination products have substantially furthered our understanding of this important biological phenomenon in humans and mice: from describing the properties of recombination hot spots in male and female meiosis to the recombination landscape along chromosomes. This progress has been accompanied by the identification of trans-acting systems that regulate the location and relative activity of individual hot spots.

Indexed as

Recombination, GeneticAnimalsCrossing Over, GeneticEvolution, MolecularFemaleGene ConversionGenetic VariationHumansMaleMeiosisMiceModels, GeneticMutationPolymorphism, Single NucleotideSelection, GeneticSex Characteristics

Identifiers

PMID20168297
PMCPMC4389181
OpenAlexW2016162945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.