ArticleMolecular & cellular proteomics : MCP2010
Regulation of protein levels in subcellular domains through mRNA transport and localized translation.
Article in Molecular & cellular proteomics : MCP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- RhoA activation in axotomy-induced neuronal death.Experimental neurology · 2018Article
- Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.Trends in neurosciences · 2017Review
- Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons.The Journal of pharmacology and experimental therapeutics · 2016Article
- Temporal patterns of gene expression during calyx of held development.Developmental neurobiology · 2016Article
- Selective expression of CSPG receptors PTPσ and LAR in poorly regenerating reticulospinal neurons of lamprey.The Journal of comparative neurology · 2014Article
- Axonal transport of neural membrane protein 35 mRNA increases axon growth.Journal of cell science · 2013Article
- Article
- Analogue encoding of physicochemical properties of proteins in their cognate messenger RNAs.Nature communications · 2013Article
- Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.Molecular and cellular neurosciences · 2011Review
- Axonal Localization of transgene mRNA in mature PNS and CNS neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development and applications of single-cell transcriptome analysis.Nature methods · 2011Review
- Profiling axonal mRNA transport.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Localized protein synthesis is increasingly recognized as a means for polarized cells to modulate protein levels in subcellular regions and the distal reaches of their cytoplasm. The axonal and dendritic processes of neurons represent functional domains of cytoplasm that can be separated from their cell body by vast distances. This separation provides a biological setting where the cell uses locally synthesized proteins to both autonomously respond to stimuli and to retrogradely signal the cell body of events occurring is this distal environment. Other cell types undoubtedly take advantage of this localized mechanism, but these have not proven as amenable for isolation of functional subcellular domains. Consequently, neurons have provided an appealing experimental platform for study of mRNA transport and localized protein synthesis. Molecular biology approaches have shown both the population of mRNAs that can localize into axons and dendrites and an unexpectedly complex regulation of their transport into these processes. Several lines of evidence point to similar complexities and specificity for regulation of mRNA translation at subcellular sites. Proteomics studies are beginning to provide a comprehensive view of the protein constituents of subcellular domains in neurons and other cell types. However, these have currently fallen short of dissecting temporal regulation of new protein synthesis in subcellular sites and mechanisms used to ferry mRNAs to these sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.