ArticleHuman molecular genetics2010
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.
Article in Human molecular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05409495 (The Effect of Titanium- Platelet Rich Fibrin in Periodontal Intrabony Defects), which is not on this map. Cited by 147 papers, 18 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Titanium- Platelet Rich Fibrin in Periodontal Intrabony Defects: A Randomized Controlled Split-Mouth Clinical Study
Who cites it
147 citing papers in PubMed, 18 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis.Oncotarget · 2025Pooled it
- ABO blood types and head and neck cancer: a systematic review with meta-analysis of observational studies.BMJ open · 2024Pooled it
- ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies.BMC medicine · 2024Pooled it
- Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis.The Journal of international medical research · 2022Pooled it
- Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities.PloS one · 2022Pooled it
- Association of ABO polymorphisms and pancreatic Cancer/ Cardiocerebrovascular disease: a meta-analysis.BMC medical genetics · 2020Pooled it
- Genetic determinants of circulating GIP and GLP-1 concentrations.JCI insight · 2017Pooled it
- Relationship between ABO blood group and pregnancy complications: a systematic literature analysis.Blood transfusion = Trasfusione del sangue · 2016Pooled it
- Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.PLoS genetics · 2016Pooled it
- ABO blood group and risk of pancreatic cancer: a study in Shanghai and meta-analysis.American journal of epidemiology · 2013Pooled it
- Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.Proceedings of the National Academy of Sciences of the United States of America · 2013Pooled it
- Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.Annals of the rheumatic diseases · 2012Pooled it
- ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.Cancer causes & control : CCC · 2012Pooled it
- ABO blood group and risk of coronary heart disease in two prospective cohort studies.Arteriosclerosis, thrombosis, and vascular biology · 2012Pooled it
- Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis.Circulation. Cardiovascular genetics · 2011Pooled it
- Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.Nature genetics · 2011Pooled it
- Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.BMC medical genetics · 2011Pooled it
- ABO blood group and the risk of placental malaria in sub-Saharan Africa.Malaria journal · 2011Pooled it
- The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.The Journal of clinical investigation · 2021Trial
- ABO blood group influences transfusion and survival after cardiac surgery.Journal of thrombosis and thrombolysis · 2014Trial
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 15 institutions in 4 countries.
Funding
Abstract
P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting soluble levels of P-selectin (sP-selectin) and ICAM-1 (sICAM-1), we performed a genome-wide association study in a sample of 4115 (sP-selectin) and 9813 (sICAM-1) individuals of European ancestry as a part of The Cohorts for Heart and Aging Research in Genome Epidemiology consortium. The most significant SNP association for sP-selectin was within the SELP gene (rs6136, P = 4.05 x 10(-61)) and for sICAM-1 levels within the ICAM-1 gene (rs3093030, P = 3.53 x 10(-23)). Both sP-selectin and sICAM-1 were associated with ABO gene variants (rs579459, P = 1.86 x 10(-41) and rs649129, P = 1.22 x 10(-15), respectively) and in both cases the observed associations could be accounted for by the A1 allele of the ABO blood group. The absence of an association between ABO blood group and platelet-bound P-selectin levels in an independent subsample (N = 1088) from the ARIC study, suggests that the ABO blood group may influence cleavage of the P-selectin protein from the cell surface or clearance from the circulation, rather than its production and cellular presentation. These results provide new insights into adhesion molecule biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.