ArticleVeterinary research
Comparative analysis of canine monocyte- and bone-marrow-derived dendritic cells.
Article in Veterinary research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluation of mineral digestibility and physiological status in adult dogs fed an organic mineral-based diet.Journal of animal science and technology · 2026Article
- A canine macrophage cell line that can be polarized provides a model for canine macrophage differentiation.Scientific reports · 2026Article
- Reapplication of the Type IV Hypersensitivity Quantitative Risk Assessment to Assess Ingredients Used on Canines.Veterinary medicine and science · 2025Review
- ExploitingCells · 2024Article
- High-parameter immunophenotyping reveals distinct immune cell profiles in pruritic dogs and cats.Frontiers in veterinary science · 2024Article
- Cannabinoid receptors in the inflammatory cells of canine atopic dermatitis.Frontiers in veterinary science · 2022Article
- Review of Dendritic Cells, Their Role in Clinical Immunology, and Distribution in Various Animal Species.International journal of molecular sciences · 2021Review
- Article
- Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways.Stem cells and development · 2017Article
- Article
- Differentiation and activation of equine monocyte-derived dendritic cells are not correlated with CD206 or CD83 expression.Immunology · 2013Article
- Suppression of canine myeloid cells by soluble factors from cultured canine tumor cells.Veterinary immunology and immunopathology · 2012Article
- Characterization of canine dendritic cells in healthy, atopic, and non-allergic inflamed skin.Journal of clinical immunology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DC) represent a heterogeneous cell family of major importance for innate immune responses against pathogens and antigen presentation during infection, cancer, allergy and autoimmunity. The aim of the present study was to characterize canine DC generated in vitro with respect to their phenotype, responsiveness to toll-like receptor (TLR) ligands and T-cell stimulatory capacity. DC were derived from monocytes (MoDC) and from bone marrow hematopoietic cells cultured with either Flt3-ligand (FL-BMDC) or with GM-CSF (GM-BMDC). All three methods generated cells with typical DC morphology that expressed CD1c, CD11c and CD14, similar to macrophages. However, CD40 was only found on DC, CD206 on MPhi and BMDC, but not on monocytes and MoDC. CD1c was not found on monocytes but on all in vitro differentiated cells. FL-BMDC and GM-BMDC were partially positive for CD4 and CD8. CD45RA was expressed on a subset of FL-BMDC but not on MoDC and GM-BMDC. MoDC and FL-DC responded well to TLR ligands including poly-IC (TLR2), Pam3Cys (TLR3), LPS (TLR4) and imiquimod (TLR7) by up-regulating MHC II and CD86. The generated DC and MPhi showed a stimulatory capacity for lymphocytes, which increased upon maturation with LPS. Taken together, our results are the basis for further characterization of canine DC subsets with respect to their role in inflammation and immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.