ArticleComparative hepatology2010
Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours.
Article in Comparative hepatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse case report and literature review of cholangiocarcinoma in horses.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Review
- Analysis of clinicopathologic and imaging features of dual-phenotype hepatocellular carcinoma.Scientific reports · 2024Article
- Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus).The Journal of veterinary medical science · 2024Article
- Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma.Journal of veterinary science · 2021Article
- Pathological and Cytological Studies on Hepatocellular Carcinoma in Cattle Slaughtered at Bishoftu Elfora Abattoir, Central Ethiopia.Veterinary medicine international · 2021Article
- Weighted gene co-expression network analysis reveals modules and hub genes associated with the development of breast cancer.Medicine · 2019Observational
- HighGenes · 2019Article
- KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma.Oncotarget · 2017Article
- Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour.Veterinary record open · 2017Article
- Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors.Oncology reports · 2015Article
- A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis.Journal of feline medicine and surgery · 2014Article
- Hepatic progenitor cells in canine and feline medicine: potential for regenerative strategies.BMC veterinary research · 2014Review
- Prognostic factors for hepatocellular carcinoma recurrence.World journal of gastroenterology · 2014Review
- Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.Experimental dermatology · 2014Article
- COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.PloS one · 2012Article
- Cytokeratin 19 expression patterns of dentigerous cysts and odontogenic keratocysts.Annals of medical and health sciences researchArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe expression of Keratin 19 (K19) was reported in a subset of hepatocellular carcinomas (HCCs). K19 positive HCCs are associated with an increased malignancy compared to K19 negative HCCs. No suitable mouse models exist for this subtype of HCC, nor is the incidence of K19 expression in hepatocellular neoplasia in model animals known. Therefore, we compared the occurrence and tumour behaviour of K19 positive hepatocellular neoplasias in dog and man.
resultsThe expression of hepatocellular differentiation (HepPar-1), biliary/progenitor cell (K7, K19), and malignancy (glypican-3) markers was semi-quantitatively assessed by immunohistochemistry. The histological grade of tumour differentiation was determined according to a modified classification of Edmondson and Steiner; the staging included intrahepatic, lymph node or distant metastases. Four of the 34 canine hepatocellular neoplasias showed K19 positivity (12%), of which two co-expressed K7. K19 positive tumours did not express HepPar-1, despite the histological evidence of a hepatocellular origin. Like in human HCC, all K19 positive hepatocellular neoplasias were glypican-3 positive and histologically poorly differentiated and revealed intra- or extrahepatic metastases whereas K19 negative hepatocellular neoplasias did not.
conclusionsK19 positive hepatocellular neoplasias are highly comparable to man and occur in 12% of canine hepatocellular tumours and are associated with a poorly differentiated histology and aggressive tumour behaviour.
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