ArticleBMC evolutionary biology2010
Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.Biomolecules · 2022Pooled it
- G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.Signal transduction and targeted therapy · 2023Review
- Distinct evolutionary trajectories of V1R clades across mouse species.BMC evolutionary biology · 2020Article
- Accelerated pseudogenization of trace amine-associated receptor genes in primates.Genes, brain, and behavior · 2019Article
- Identifying human diamine sensors for death related putrescine and cadaverine molecules.PLoS computational biology · 2018Article
- Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders.Frontiers in pharmacology · 2018Article
- Methamphetamine induces trace amine-associated receptor 1 (TAAR1) expression in human T lymphocytes: role in immunomodulation.Journal of leukocyte biology · 2016Article
- Article
- Evolutionary Conservation of 3-Iodothyronamine as an Agonist at the Trace Amine-Associated Receptor 1.European thyroid journal · 2015Article
- An animal model of differential genetic risk for methamphetamine intake.Frontiers in neuroscience · 2015Review
- Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.PloS one · 2015Article
- Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans.PloS one · 2015Article
- Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1.Pharmacology, biochemistry, and behavior · 2012Article
- Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1).Journal of medicinal chemistry · 2012Article
- Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte.American journal of human genetics · 2011Article
- Article
- The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.Journal of neurochemistry · 2011Review
- Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor that acts as a modulator in brain monoaminergic systems. Other trace amine associated receptors appear to relate to environmental perception and show a birth-and-death pattern in mammals similar to olfactory receptors.
resultsAcross mammals, avians, and amphibians, the TAAR1 gene is intact and appears to be under strong purifying selection based on rates of amino acid fixation compared to neutral mutations. We have found that in dogs it has become a pseudogene. Our analyses using a comparative genetics approach revealed that the pseudogenization event predated the emergence of the Canini tribe rather than being coincident with canine domestication. By assessing the effects of the TAAR1 agonist beta-phenylethylamine on [3H]dopamine uptake in canine striatal synaptosomes and comparing the degree and pattern of uptake inhibition to that seen in other mammals, including TAAR1 knockout mice, wild type mice and rhesus monkey, we found that the TAAR1 pseudogenization event resulted in an uncompensated loss of function.
conclusionThe gene family has seen expansions among certain mammals, notably rodents, and reductions in others, including primates. By placing the trace amine associated receptors in an evolutionary context we can better understand their function and their potential associations with behavior and neurological disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.