ArticleBMC medical genetics2010
Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
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14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals.Molecular nutrition & food research · 2019Pooled it
- GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.Science (New York, N.Y.) · 2013Pooled it
- Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.American journal of epidemiology · 2013Pooled it
- Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.PLoS genetics · 2012Pooled it
- A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.Nature genetics · 2011Pooled it
- Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults.Journal of personalized medicine · 2023Article
- Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis.Scientific reports · 2022Article
- The role of exogenous Fibrinogen in cardiac surgery: stop bleeding or induce cardiovascular disease.Molecular biology reports · 2020Review
- Evaluation of single nucleotide polymorphisms in 6 candidate genes and carotid intima-media thickness in community-dwelling residents.PloS one · 2020Article
- A novel ultrasonic method for evaluation of blood clotting parameters.Journal of medical ultrasonics (2001) · 2018Article
- Article
- Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome.International journal of molecular and cellular medicine · 2016Article
- Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetic mellitus.Disease markers · 2014Article
- A genetic instrument for Mendelian randomization of fibrinogen.European journal of epidemiology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough plasma fibrinogen levels are related to cardiovascular risk, data regarding the role of fibrinogen genetic variation in myocardial infarction (MI) or coronary artery disease (CAD) etiology remain inconsistent. The purpose of the present study was to investigate the effect of fibrinogen A (FGA), fibrinogen B (FGB) and fibrinogen G (FGG) gene SNPs and haplotypes on susceptibility to CAD in a homogeneous Greek population.
methodsWe genotyped for rs2070022, rs2070016, rs2070006 in FGA gene, the rs7673587, rs1800789, rs1800790, rs1800788, rs1800787, rs4681 and rs4220 in FGB gene and for the rs1118823, rs1800792 and rs2066865 SNPs in FGG gene applying an arrayed primer extension-based genotyping method (APEX-2) in a sample of CAD patients (n = 305) and controls (n = 305). Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), before and after adjustment for potential confounders.
resultsNone of the FGA and FGG SNPs and FGA, FGB, FGG and FGA-FGG haplotypes was associated with disease occurrence after adjustment. Nevertheless, rs1800787 and rs1800789 SNPs in FGB gene seem to decrease the risk of CAD, even after adjustment for potential confounders (OR = 0.42, 95%CI: 0.19-0.90, p = 0.026 and OR = 0.44, 95%CI:0.21-0.94, p = 0.039, respectively).
conclusionsFGA and FGG SNPs as well as FGA, FGB, FGG and FGA-FGG haplotypes do not seem to be important contributors to CAD occurrence in our sample. On the contrary, FGB rs1800787 and rs1800789 SNPs seem to confer protection to disease onset lowering the risk by about 50% in homozygotes for the minor alleles.
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