ArticleBMC cancer2010
Novel genetic variants in miR-191 gene and familial ovarian cancer.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling.International journal of nanomedicine · 2025Article
- Similar miRNomic signatures characterize the follicular fluids collected after follicular and luteal phase stimulations in the same ovarian cycle.Journal of assisted reproduction and genetics · 2020Article
- Framework for microRNA variant annotation and prioritization using human population and disease datasets.Human mutation · 2019Article
- Circular RNAOncoTargets and therapy · 2019Article
- Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway.Oncology research · 2018Article
- Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis.OncoTargets and therapy · 2018Article
- miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA).Oncotarget · 2017Review
- Involvement of the miR-462/731 cluster in hypoxia response in Megalobrama amblycephala.Fish physiology and biochemistry · 2017Article
- [Expression of microRNA-191 in T lymphoblastic leukemia/lymphoma and its underlying mechanism].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2016Article
- miRVaS: a tool to predict the impact of genetic variants on miRNAs.Nucleic acids research · 2016Article
- Decreased miR-198 expression and its prognostic significance in human gastric cancer.World journal of surgical oncology · 2016Article
- Article
- Two Virus-Induced MicroRNAs Known Only from Teleost Fishes Are Orthologues of MicroRNAs Involved in Cell Cycle Control in Humans.PloS one · 2015Article
- MiR-191 inhibits TNF-α induced apoptosis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1.International journal of clinical and experimental pathology · 2015Article
- The clinical significance and regulation mechanism of hypoxia-inducible factor-1 and miR-191 expression in pancreatic cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Role of miR-191/425 cluster in tumorigenesis and diagnosis of gastric cancer.International journal of molecular sciences · 2014Article
- miR-191: an emerging player in disease biology.Frontiers in genetics · 2014Review
- Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma.Neoplasia (New York, N.Y.) · 2011Article
- MicroRNA-mediated drug resistance in breast cancer.Clinical epigenetics · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHalf of the familial aggregation of ovarian cancer can't be explained by any known risk genes, suggesting the existence of other genetic risk factors. Some of these unknown factors may not be traditional protein encoding genes. MicroRNA (miRNA) plays a critical role in tumorigenesis, but it is still unknown if variants in miRNA genes lead to predisposition to cancer. Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. METHODS AND
resultsTo test this hypothesis in familial ovarian cancer, we screened for genetic variants in thirty selected miRNA genes, which are predicted to regulate key ovarian cancer genes and are reported to be misexpressed in ovarian tumor tissues, in eighty-three patients with familial ovarian cancer. All of the patients are non-carriers of any known BRCA1/2 or mismatch repair (MMR) gene mutations. Seven novel genetic variants were observed in four primary or precursor miRNA genes. Among them, three rare variants were found in the precursor or primary precursor of the miR-191 gene. In functional assays, the one variant located in the precursor of miR-191 resulted in conformational changes in the predicted secondary structures, and consequently altered the expression of mature miR-191. In further analysis, we found that this particular variant exists in five family members who had ovarian cancer.
conclusionsOur findings suggest that there are novel genetic variants in miRNA genes, and those certain genetic variants in miRNA genes can affect the expression of mature miRNAs and, consequently, might alter the regulation of TSGs or oncogenes. Additionally, the variant might be potentially associated with the development of familial ovarian cancer.
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