ReviewCurrent drug metabolism2009
Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates.
Review in Current drug metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- A cell culture system to model pharmacokinetics using adjustable-volume perfused mixing chambers.Toxicology in vitro : an international journal published in association with BIBRA · 2023Article
- The Combination of Electrochemistry and Microfluidic Technology in Drug Metabolism Studies.ChemistryOpen · 2022Review
- Microfluidics - The State-of-the-Art Technology for Pharmaceutical Application.Advanced pharmaceutical bulletin · 2022Review
- Organ-on-a-chip engineering: Toward bridging the gap between lab and industry.Biomicrofluidics · 2020Review
- Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices.Micromachines · 2019Article
- Numerical Investigations of Hepatic Spheroids Metabolic Reactions in a Perfusion Bioreactor.Frontiers in bioengineering and biotechnology · 2019Article
- Comparison of the degradation behavior of PLGA scaffolds in micro-channel, shaking, and static conditions.Biomicrofluidics · 2018Article
- Flow-perfusion bioreactor system for engineered breast cancer surrogates to be used in preclinical testing.Journal of tissue engineering and regenerative medicine · 2017Article
- Bioengineering considerations in liver regenerative medicine.Journal of biological engineering · 2017Review
- Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution ofTechnology · 2015Article
- Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients.Journal of cheminformatics · 2015Article
- Microfluidics-based in vivo mimetic systems for the study of cellular biology.Accounts of chemical research · 2014Article
- Organotypic liver culture models: meeting current challenges in toxicity testing.Critical reviews in toxicology · 2012Review
- Physiologically based pharmacokinetic models: integration of in silico approaches with micro cell culture analogues.Current drug metabolism · 2012Review
- Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis.Cellular and molecular bioengineering · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
One of the fundamental challenges facing the development of new chemical entities within the pharmaceutical industry is the extrapolation of key in vivo parameters from in vitro cell culture assays and animal studies. Development of microscale devices and screening assays incorporating primary human cells can potentially provide better, faster and more efficient prediction of in vivo toxicity and clinical drug performance. With this goal in mind, large strides have been made in the area of microfluidics to provide in vitro surrogates that are designed to mimic the physiological architecture and dynamics. More recent advancements have been made in the development of in vitro analogues to physiologically-based pharmacokinetic (PBPK) models - a mathematical model that represents the body as interconnected compartments specific for a particular organ. In this review we highlight recent advancements in human hepatocyte microscale culture, and describe the next generation of integrated devices, whose potential allows for the high throughput assessment of drug metabolism, distribution and pharmacokinetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.