ArticleBiochemistry2010
Conformation-dependent formation of the G[8-5]U intrastrand cross-link in 5-bromouracil-containing G-quadruplex DNA induced by UVA irradiation.
Article in Biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions inScientific reports · 2018Article
- 5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2'-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity.RSC advances · 2018Article
- Mechanism studies of addition reactions between the pyrimidine type radicals and their 3'/5' neighboring deoxyguanosines.RSC advances · 2018Article
- In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?Journal of nucleic acids · 2017Review
- Electron stimulated desorption of anions from native and brominated single stranded oligonucleotide trimers.The Journal of chemical physics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
G-quadruplex motifs are known to be present in telomeres of human and other organisms. Recent bioinformatic studies also revealed the widespread existence of these motifs in promoter regions of human genes. Treatment of cultured cells with 5-bromo-2'-deoxyuridine ((Br)dU) is known to result in the substitution of DNA thymidine with (Br)dU; such replacement has been shown to sensitize cells to killing induced by UV light. Our previous studies revealed that the exposure of (Br)dU-carrying duplex DNA or (Br)dU-treated MCF-7 cells to UVB light could lead to the facile formation of intrastrand cross-link products initiated from (Br)dU. Here we found that the exposure of (Br)dU-bearing G-quadruplex DNA to UVA light could also give rise to the efficient formation of the G[8-5]U intrastrand cross-link, where the C8 of guanine in the external G-tetrad is covalently linked with the C5 of its adjacent 3' uracil in the loop region. In addition, the yield for the cross-link product is dependent on the conformation of the G-quadruplex. Together, the formation of intrastrand cross-link in G-quadruplex motifs may account for the photocytotoxic effect induced by (Br)dU incorporation, and the (Br)dU-mediated photo-cross-linking may constitute a useful method for monitoring the different conformations of G-quadruplex folding.
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Registered trials
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