ArticleJournal of biomedical materials research. Part A2010
Chronic inflammatory responses to microgel-based implant coatings.
Article in Journal of biomedical materials research. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self-Assembly within Highly Crowded Microgel Pastes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Encapsulation Strategy Matters: Pre- and Post-Loading of Macromolecules into Surface-Supported Microgels Formed via Vaterite Templates.ACS materials Au · 2025Article
- Analysis of key immune genes in mesenchymal stem cells in a 3D environment.American journal of stem cells · 2025Article
- Review
- Insights in the host response towards biomaterial-based scaffolds for cancer therapy.Frontiers in bioengineering and biotechnology · 2023Review
- Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review.Biomaterials research · 2022Review
- Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings.Bioactive materials · 2021Review
- Particle Stiffness and Surface Topography Determine Macrophage-Mediated Removal of Surface Adsorbed Particles.Advanced healthcare materials · 2021Article
- Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Review
- A Materials Roadmap to Functional Neural Interface Design.Advanced functional materials · 2018Article
- Methods for Generating Hydrogel Particles for Protein Delivery.Annals of biomedical engineering · 2016Review
- Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.RSC advances · 2015Article
- Topographical cues regulate the crosstalk between MSCs and macrophages.Biomaterials · 2015Article
- Host response to microgel coatings on neural electrodes implanted in the brain.Journal of biomedical materials research. Part A · 2014Article
- Ultralow protein adsorbing coatings from clickable PEG nanogel solutions: benefits of attachment under salt-induced phase separation conditions and comparison with PEG/albumin nanogel coatings.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Modulation of the foreign body reaction for implants in the subcutaneous space: microdialysis probes as localized drug delivery/sampling devices.Journal of diabetes science and technology · 2011Article
- Evaluation of madurahydroxylactone as a slow release antibacterial implant coating.The open biomedical engineering journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel-coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel-coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared to unmodified PET disks. Furthermore, microgel-coated samples contained significantly higher levels of macrophages (80%) than unmodified PET controls. These results demonstrate that microgel coatings reduce chronic inflammation to implanted biomaterials. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.