ArticleJournal of general internal medicine2010
Antihypertensive medication adherence, ambulatory visits, and risk of stroke and death.
Article in Journal of general internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Factors affecting follow-up non-attendance in patients with Type 2 diabetes mellitus and hypertension: a systematic review.Singapore medical journal · 2019Pooled it
- Adherence to Antihypertensive Medications and Stroke Risk: A Dose-Response Meta-Analysis.Journal of the American Heart Association · 2017Pooled it
- Trial
- The Association Between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure: Findings From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- Pharmacist intervention for blood pressure control: medication intensification and adherence.Journal of the American Society of Hypertension : JASH · 2015Trial
- "My doctor has changed my pills without telling me": impact of generic medication switches in stroke survivors.Journal of behavioral medicine · 2014Trial
- Obesity treatment for socioeconomically disadvantaged patients in primary care practice.Archives of internal medicine · 2012Trial
- Improving refill adherence and hypertension control in black patients: Wisconsin TEAM trial.Journal of the American Pharmacists Association : JAPhATrial
- A successful intervention to improve medication adherence in Black patients with hypertension: Mediation analysis of 28-site TEAM trial.Journal of the American Pharmacists Association : JAPhATrial
- Cost-effectiveness of Wisconsin TEAM model for improving adherence and hypertension control in black patients.Journal of the American Pharmacists Association : JAPhATrial
- Health coaching to improve hypertension treatment in a low-income, minority population.Annals of family medicineTrial
- Antihypertensive Medication Patterns in Patients with Hypertension that is Harder to Control: Insights from the EnligHTN Study.Advances in therapy · 2026Article
- Hypertension Care Quality and Incidence of Complications Among Hypertensive Patients With Disabilities in Korea: An Analysis of a Cohort Study Using National Health Insurance Data.Journal of Korean medical science · 2026Article
- Article
- Medication Adherence in the Real World: Lessons from the Diuretic Comparison Project.Journal of clinical medicine · 2025Article
- Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study.Frontiers in pharmacology · 2025Article
- Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension.Journal of the American Heart Association · 2024Article
- The Economic Burden of Atherosclerotic Cardiovascular Disease in Italy.Clinical drug investigation · 2024Article
- A scoping review on the factors associated with the lost to follow-up (LTFU) amongst patients with chronic disease in ambulatory care of high-income countries (HIC).BMC health services research · 2023Article
- Perception of hypertension and adherence to hypertension treatment among patients attending a hospital in western Iran: A cross-sectional study.Health science reports · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study seeks to determine whether antihypertensive medication refill adherence, ambulatory visits, and type of antihypertensive medication exposures are associated with decreased stroke and death for community-dwelling hypertensive patients.
methodsThis retrospective cohort study included all chronic medication-treated hypertensives enrolled in Tennessee's Medicaid program (TennCare) for 3-7 years during the period 1994-2000 (n = 49,479). Health care utilization patterns were evaluated using administrative data linked to vital records during a 2-year run-in period and 1- to 5-year follow-up period. Antihypertensive medication refill adherence was calculated using pharmacy records.
resultsAssociations with stroke and death were assessed using Cox proportional hazards modeling. Stroke occurred in 619 patients (1.25%) and death in 2,051 (4.15%). Baseline antihypertensive medication refill adherence was associated with decreased multivariate hazards of stroke [hazard ratio (HR) 0.91; 95% confidence interval (CI), 0.86-0.97 for 15% increase in adherence]. Adherence in the follow-up period was associated with decreased hazards of stroke (HR 0.92; CI 0.87-0.96) and death (HR 0.93; CI 0.90-0.96). Baseline ambulatory visits were associated with decreased death (HR 0.99; CI 0.98-1.00). Four major classes of antihypertensive agents were associated with mortality reduction. Only thiazide-type diuretic use was associated with decreased stroke (HR 0.89; CI 0.85-0.93).
conclusionsAmbulatory visits and antihypertensive medication exposures are associated with reduced mortality. Increasing adherence by one pill per week for a once-a-day regimen reduces the hazard of stroke by 8-9% and death by 7%.
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