ArticleEuropean journal of applied physiology2010
Effects of a high-fat meal on pulmonary function in healthy subjects.
Article in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Effects of obesity on lung volume and capacity in children and adolescents: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016Pooled it
- Trial
- A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.Journal of immunology (Baltimore, Md. : 1950) · 2018Trial
- Does chronic physical activity level modify the airway inflammatory response to an acute bout of exercise in the postprandial period?Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Trial
- Effects of thirty and sixty minutes of moderate-intensity aerobic exercise on postprandial lipemia and inflammation in overweight men: a randomized cross-over study.Journal of the International Society of Sports Nutrition · 2016Trial
- The effects of antioxidant vitamin supplementation on expiratory flow rates at rest and during exercise.European journal of applied physiology · 2015Trial
- Does moderate intensity exercise attenuate the postprandial lipemic and airway inflammatory response to a high-fat meal?BioMed research international · 2015Trial
- The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal.European journal of applied physiology · 2014Trial
- Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults.Metabolites · 2022Article
- Asthma and Technology in Emerging African American Adults (The ATHENA Project): Protocol for a Trial Using the Multiphase Optimization Strategy Framework.JMIR research protocols · 2022Article
- Acute peat smoke inhalation sensitizes rats to the postprandial cardiometabolic effects of a high fat oral load.The Science of the total environment · 2018Article
- High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.The Journal of biological chemistry · 2018Article
- Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children.International journal of obesity (2005) · 2017Article
- Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.Respiratory medicine · 2017Article
- Review
- Asthma control in pregnancy is associated with pre-conception dietary patterns.Public health nutrition · 2016Article
- Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal.Journal of diabetes research · 2016Article
- Transcriptional alterations of ET-1 axis and DNA damage in lung tissue of a rat obesity model.DNA and cell biology · 2015Article
- Immunometabolism in obese asthmatics: are we there yet?Nutrients · 2013Review
- Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus).American journal of primatology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has important health consequences, including elevating risk for heart disease, diabetes, and cancer. A high-fat diet is known to contribute to obesity. Little is known regarding the effect of a high-fat diet on pulmonary function, despite the dramatic increase in the prevalence of respiratory ailments (e.g., asthma). The purpose of our study was to determine whether a high-fat meal (HFM) would increase airway inflammation and decrease pulmonary function in healthy subjects. Pulmonary function tests (PFT) (forced expiratory volume in 1-s, forced vital capacity, forced expiratory flow at 25-75% of vital capacity) and exhaled nitric oxide (eNO; airway inflammation) were performed in 20 healthy (10 men, 10 women), inactive subjects (age 21.9 +/- 0.4 years) pre and 2 h post HFM (1 g fat/1 kg body weight; 74.2 +/- 4.1 g fat). Total cholesterol, triglycerides, and C-reactive protein (CRP; systemic inflammation) were determined via a venous blood sample pre and post HFM. Body composition was measured via dual energy X-ray absorptiometry. The HFM significantly increased total cholesterol by 4 +/- 1%, and triglycerides by 93 +/- 3%. ENO also increased (p < 0.05) due to the HFM by 19 +/- 1% (pre 17.2 +/- 1.6; post 20.6 +/- 1.7 ppb). ENO and triglycerides were significantly related at baseline and post-HFM (r = 0.82, 0.72 respectively). Despite the increased eNO, PFT or CRP did not change (p > 0.05) with the HFM. These results demonstrate that a HFM, which leads to significant increases in total cholesterol, and especially triglycerides, increases exhaled NO. This suggests that a high-fat diet may contribute to chronic inflammatory diseases of the airway and lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.