ArticleActa crystallographica. Section A, Foundations of crystallography2010
Five-dimensional crystallography.
Article in Acta crystallographica. Section A, Foundations of crystallography, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Probing the modulation of enzyme kinetics by multi-temperature, time-resolved serial crystallography.Nature communications · 2025Article
- Exploring the dynamics of allostery through multi-dimensional crystallography.Biophysical reviews · 2024Review
- A snapshot love story: what serial crystallography has done and will do for us.Acta crystallographica. Section D, Structural biology · 2024Review
- Article
- Deconvolution of dynamic heterogeneity in protein structure.Structural dynamics (Melville, N.Y.) · 2024Review
- KINNTREX: a neural network to unveil protein mechanisms from time-resolved X-ray crystallography.IUCrJ · 2024Article
- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- BioCARS: Synchrotron facility for probing structural dynamics of biological macromolecules.Structural dynamics (Melville, N.Y.) · 2024Article
- Blue and red in the protein world: Photoactive yellow protein and phytochromes as revealed by time-resolved crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- Xtrapol8 enables automatic elucidation of low-occupancy intermediate-states in crystallographic studies.Communications biology · 2022Article
- Discerning best practices in XFEL-based biological crystallography - standards for nonstandard experiments.IUCrJ · 2021Review
- A tool for visualizing protein motions in time-resolved crystallography.Structural dynamics (Melville, N.Y.) · 2020Article
- Article
- Watching Proteins Function with Time-resolved X-ray Crystallography.Journal of physics D: Applied physics · 2017Article
- A short history of structure based research on the photocycle of photoactive yellow protein.Structural dynamics (Melville, N.Y.) · 2017Review
- Time-resolved crystallography and protein design: signalling photoreceptors and optogenetics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Enzyme transient state kinetics in crystal and solution from the perspective of a time-resolved crystallographer.Structural dynamics (Melville, N.Y.) · 2014Article
- Protein energy landscapes determined by five-dimensional crystallography.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Spectroscopic studies of model photo-receptors: validation of a nanosecond time-resolved micro-spectrophotometer design using photoactive yellow protein and α-phycoerythrocyanin.International journal of molecular sciences · 2013Article
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4 authors.
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Abstract
A method for determining a comprehensive chemical kinetic mechanism in macromolecular reactions is presented. The method is based on five-dimensional crystallography, where, in addition to space and time, temperature is also taken into consideration and an analysis based on singular value decomposition is applied. First results of such a time-resolved crystallographic study are presented. Temperature-dependent time-resolved X-ray diffraction measurements were conducted on the newly upgraded BioCARS 14-ID-B beamline at the Advanced Photon Source and aimed at elucidating a comprehensive kinetic mechanism of the photoactive yellow protein photocycle. Extensive time series of crystallographic data were collected at two temperatures, 293 K and 303 K. Relaxation times of the reaction extracted from these time series exhibit measurable differences for the two temperatures, hence demonstrating that five-dimensional crystallography is feasible.
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