ArticleJournal of immunology (Baltimore, Md. : 1950)2010
The major locus for mouse adenovirus susceptibility maps to genes of the hematopoietic cell surface-expressed LY6 family.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis.Journal of virology · 2025Article
- APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis.Frontiers in pharmacology · 2024Article
- Adeno-Associated Viral Vectors as Versatile Tools for Parkinson's Research, Both for Disease Modeling Purposes and for Therapeutic Uses.International journal of molecular sciences · 2021Review
- Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host.FEBS letters · 2019Review
- Review
- Emerging Role of LY6E in Virus-Host Interactions.Viruses · 2019Review
- The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- CD4-Dependent Modulation of HIV-1 Entry by LY6E.Journal of virology · 2019Article
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids.PloS one · 2019Article
- Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4Immunity, inflammation and disease · 2017Article
- Interferon-inducible LY6E Protein Promotes HIV-1 Infection.The Journal of biological chemistry · 2017Article
- Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1.Journal of virology · 2017Article
- Article
- Biochemistry and pathophysiology of intravascular and intracellular lipolysis.Genes & development · 2013Review
- Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis.mBio · 2012Article
- A diverse range of gene products are effectors of the type I interferon antiviral response.Nature · 2011Article
- Host genetic variation in susceptibility to Punta Toro virus.Virus research · 2011Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
Susceptibility to mouse adenovirus type 1 is associated with the major quantitative trait locus Msq1. Msq1 was originally mapped to a 13-Mb region of mouse chromosome (Chr) 15 in crosses between SJL/J and BALB/cJ inbred mice. We have now narrowed Msq1 to a 0.75-Mb interval from 74.68 to 75.43 Mb, defined by two anonymous markers, rs8259436 and D15Spn14, using data from 1396 backcross mice. The critical interval includes 14 Ly6 or Ly6-related genes, including Ly6a (encoding Sca-1/TAP), Ly6e (Sca-2/Tsa1), Ly6g (Gr-1), and gpihbp1 (GPI-anchored high-density lipoprotein-binding protein 1), as well as the gene encoding an aldosterone synthase (Cyp11b2). The Ly6 family members are attractive candidates for virus susceptibility genes because their products are GPI-anchored membrane proteins expressed on lymphoid and myeloid cells, with proposed functions in cell adhesion and cell signaling. To determine interstrain variation in susceptibility and produce additional resources for cloning Msq1, we assayed the susceptibility phenotype of four previously untested inbred mouse strains. Susceptibility of strain 129S6/SvEvTac was subsequently localized to the Ly6 complex region, using polymorphic genetic markers on Chr 15 in a population of 271 (129S6/SvEvTac x BALB/cJ)F(1) x BALB/cJ backcross mice. We identified a major 129S6/SvEvTac susceptibility allele, Msq1(129S6), on Chr 15 in the same region as Msq1(SJL). The results indicate that a major host factor in mouse adenovirus type 1 susceptibility is likely to be a member of the Ly6 gene family.
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